Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins

Zhi Yong Yang, Rafael Delgado, Ling Xu, Robert F. Todd, Elizabeth G. Nabel, Anthony Sanchez, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanisms by which Ebola virus evades detection and infects cells to cause hemorrhagic fever have not been defined, though its glycoprotein, synthesized in either a secreted or transmembrane form, is likely involved. Here the secreted glycoprotein was found to interact wit neutrophils through CD16b, the neutrophil-specific form of the Fcγ receptor III, whereas the transmembrane glycoprotein was found to interact with endothelial cells but not neutrophils. A murine retroviral vector pseudotyped with the transmembrane glycoprotein preferentially infected endothelial cells. Thus, the secreted glycoprotein inhibits early neutrophil activation, which likely affects the host response to infection, whereas binding of the transmembrane glycoprotein to endothelial cells may contribute to the hemorrhagic symptoms of this disease.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalScience
Volume279
Issue number5353
DOIs
StatePublished - Feb 13 1998
Externally publishedYes

ASJC Scopus subject areas

  • General

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