Distant metastasis in breast cancer

Molecular mechanisms and a search for therapeutic targets

Belinda S. Parker, Saraswati Sukumar

Research output: Contribution to journalArticle

Abstract

Distant metastasis is responsible for the death of nearly 45,000 women per year in the US alone. At present, we have no clear understanding about the genetic events that govern the ability of breast cancer cells to settle at and colonize in specific sites in the body. This information is critical for developing therapeutic strategies that would target the tumor cells and their supporting environment at distant sites. This review will discuss investigations on 1) the steps of the metastatic pathway, 2) innovative technologies such as radiologic imaging and molecular manipulations of cells that would help us to study metastasis in real time, 3) strengths and weaknesses of current models for studying metastasis, and 4) how best to design large comprehensive gene searches during metastatic progression of breast cancer. These advances will enable the development of therapies targeted towards blocking the outgrowth of metastatic cells.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalCancer Biology and Therapy
Volume2
Issue number1
StatePublished - Jan 2003

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Breast Neoplasms
Neoplasm Metastasis
Molecular Imaging
Therapeutics
Technology
Genes
Neoplasms

Keywords

  • Animal models
  • Bone
  • Breast
  • Expression analysis
  • Genes
  • Metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

Cite this

Distant metastasis in breast cancer : Molecular mechanisms and a search for therapeutic targets. / Parker, Belinda S.; Sukumar, Saraswati.

In: Cancer Biology and Therapy, Vol. 2, No. 1, 01.2003, p. 14-21.

Research output: Contribution to journalArticle

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