Distance transforms in multi channel MR image registration

Min Chen, Aaron Carass, John Bogovic, Pierre Louis Bazin, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Deformable registration techniques play vital roles in a variety of medical imaging tasks such as image fusion, segmentation, and post-operative surgery assessment. In recent years, mutual information has become one of the most widely used similarity metrics for medical image registration algorithms. Unfortunately, as a matching criteria, mutual information loses much of its effectiveness when there is poor statistical consistency and a lack of structure. This is especially true in areas of images where the intensity is homogeneous and information is sparse. Here we present a method designed to address this problem by integrating distance transforms of anatomical segmentations as part of a multi-channel mutual information framework within the registration algorithm. Our method was tested by registering real MR brain data and comparing the segmentation of the results against that of the target. Our analysis showed that by integrating distance transforms of the the white matter segmentation into the registration, the overall segmentation of the registration result was closer to the target than when the distance transform was not used.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationImage Processing
StatePublished - 2011
EventMedical Imaging 2011: Image Processing - Lake Buena Vista, FL, United States
Duration: Feb 14 2011Feb 16 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2011: Image Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Distance Transform
  • Image registration
  • Magnetic resonance imaging
  • Multidimensional signal processing
  • Spatial normalization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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