Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-α in patients with septic shock

Manfred Weiss, Guenther Fischer, Eberhard Barth, Eva Boneberg, Elisabeth Marion Schneider, Michael Georgieff, Thomas Hartung

Research output: Contribution to journalArticle

Abstract

Over a 6 month period, in 192 patients admitted to the intensive care unit (ICU), a longitudinal analysis of whole blood lipopolysaccharide (LPS)-induced ex vivo cytokine production was performed on a daily basis until discharge from the ICU or death. Twenty-one patients with proven infections were in septic shock for the first time and for at least 3 days' duration. Ex vivo LPS-inducible release of granulocyte colony-stimulating factor (G-CSF) was upregulated and that of TNF-α was downregulated in patients with septic shock, regardless whether they survived or died. In conclusion, LPS-induced ex vivo TNF-α and G-CSF cytokine release by monocytes is regulated differentially in patients with septic shock. Since upregulation of LPS-induced production of G-CSF occurred earlier in survivors than in non-survivors, rapidly elevated and sustained G-CSF responsiveness may contribute to survival in septic shock.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalCytokine
Volume13
Issue number1
DOIs
StatePublished - Jan 7 2001
Externally publishedYes

Fingerprint

Granulocyte Colony-Stimulating Factor
Septic Shock
Lipopolysaccharides
Intensive care units
Intensive Care Units
Cytokines
Survivors
Monocytes
Blood
Up-Regulation
Down-Regulation
Survival
Infection

Keywords

  • Granulocyte colony-stimulating factor
  • LPS
  • Sepsis
  • Septic shock
  • TNF

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-α in patients with septic shock. / Weiss, Manfred; Fischer, Guenther; Barth, Eberhard; Boneberg, Eva; Schneider, Elisabeth Marion; Georgieff, Michael; Hartung, Thomas.

In: Cytokine, Vol. 13, No. 1, 07.01.2001, p. 51-54.

Research output: Contribution to journalArticle

Weiss, Manfred ; Fischer, Guenther ; Barth, Eberhard ; Boneberg, Eva ; Schneider, Elisabeth Marion ; Georgieff, Michael ; Hartung, Thomas. / Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-α in patients with septic shock. In: Cytokine. 2001 ; Vol. 13, No. 1. pp. 51-54.
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