Dissociation of LPS-induced monocytic ex vivo production of granulocyte colony-stimulating factor (G-CSF) and TNF-α in patients with septic shock

Manfred Weiss, Guenther Fischer, Eberhard Barth, Eva Boneberg, Elisabeth Marion Schneider, Michael Georgieff, Thomas Hartung

Research output: Contribution to journalArticle

Abstract

Over a 6 month period, in 192 patients admitted to the intensive care unit (ICU), a longitudinal analysis of whole blood lipopolysaccharide (LPS)-induced ex vivo cytokine production was performed on a daily basis until discharge from the ICU or death. Twenty-one patients with proven infections were in septic shock for the first time and for at least 3 days' duration. Ex vivo LPS-inducible release of granulocyte colony-stimulating factor (G-CSF) was upregulated and that of TNF-α was downregulated in patients with septic shock, regardless whether they survived or died. In conclusion, LPS-induced ex vivo TNF-α and G-CSF cytokine release by monocytes is regulated differentially in patients with septic shock. Since upregulation of LPS-induced production of G-CSF occurred earlier in survivors than in non-survivors, rapidly elevated and sustained G-CSF responsiveness may contribute to survival in septic shock.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalCytokine
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 7 2001
Externally publishedYes

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Keywords

  • Granulocyte colony-stimulating factor
  • LPS
  • Sepsis
  • Septic shock
  • TNF

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

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