Dissociation between left ventricular untwisting and filling accentuation by catecholamines

Frank E. Rademakers, Maurice B. Buchalter, Walter J. Rogers, Elias Zerhouni, Myron Weisfeldt, James L Weiss, Edward Shapiro

Research output: Contribution to journalArticle

Abstract

Background. Efficient early diastolic filling is essential for normal cardiac function. Diastolic suction, as evidenced by a decreasing left ventricular pressure during early filling, could result from restoring forces (the release of potential energy stored during systolic deformation) dependent on myofilament relaxation. Although these restoring forces have been envisioned within individual myofibers, recent studies suggest that gross fiber rearrangement involving the connective tissue network occurs early in diastole. This may lead to the release of potential energy stored during systole and suction-aided filling. Methods and Results. To establish precisely the timing and extent of restoration of the systolic torsional deformation of the left ventricle with respect to early filling at baseline and with enhanced relaxation, we studied untwisting during control conditions and with catecholamine stimulation. Using noninvasive and nondestructive magnetic resonance tagging, torsional deformation of the left ventricle was measured at 20-msec intervals in 10 open-chest, atrially paced dogs, starting at aortic valve closure. Eight equiangular tags intersected the epicardium and endocardium in three short-axis imaging planes (base, mid, and apex). From the intersection points, epicardial and endocardial circumferential chord and arc lengths were measured and angular twist of mid and apical levels with respect to the base (maximal torsion and its reversal, untwisting) was calculated. Echo-Doppler provided timing of aortic valve closure and of mitral valve opening. Zero torsion was defined at end diastole. Torsion at the apical level reversed rapidly between its maximum and the time immediately after mitral valve opening: from 7.0±5.8° to 3.2±5.4° and 12.0±8.5° to 6.9±7.8° (mean±SD, both p

Original languageEnglish (US)
Pages (from-to)1572-1581
Number of pages10
JournalCirculation
Volume85
Issue number4
StatePublished - Apr 1992

Fingerprint

Diastole
Suction
Aortic Valve
Mitral Valve
Heart Ventricles
Catecholamines
Endocardium
Myofibrils
Systole
Pericardium
Ventricular Pressure
Connective Tissue
Magnetic Resonance Spectroscopy
Thorax
Dogs

Keywords

  • Biomechanics
  • Dobutamine
  • Left ventricular filling
  • Regional function

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Dissociation between left ventricular untwisting and filling accentuation by catecholamines. / Rademakers, Frank E.; Buchalter, Maurice B.; Rogers, Walter J.; Zerhouni, Elias; Weisfeldt, Myron; Weiss, James L; Shapiro, Edward.

In: Circulation, Vol. 85, No. 4, 04.1992, p. 1572-1581.

Research output: Contribution to journalArticle

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AU - Shapiro, Edward

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