Dissociating the effects of Sternberg working memory demands in prefrontal cortex

Mario Altamura, Brita Elvevåg, Giuseppe Blasi, Alessandro Bertolino, Joseph H. Callicott, Daniel Weinberger, Venkata Mattay, Terry E. Goldberg

Research output: Contribution to journalArticle

Abstract

Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the present functional resonance imaging (fMRI) study was to map within prefrontal cortex locales that are selectively load sensitive, delay sensitive, or both. We studied 18 right-handed normal subjects with fMRI at 3 Tesla during a block design version of the Sternberg task. WM load was manipulated by varying the memory set size (3, 5, or 8 letters). The effect of memory maintenance was examined by employing two time delays (1 s and 6 s) between the letter set and probe stimuli. The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas. Moreover, regions of prefrontal cortex on the right (BA 46) were found to be exclusively affected by load. These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas.

Original languageEnglish (US)
Pages (from-to)103-114
Number of pages12
JournalPsychiatry Research - Neuroimaging
Volume154
Issue number2
DOIs
StatePublished - Feb 28 2007
Externally publishedYes

Fingerprint

Prefrontal Cortex
Short-Term Memory
Maintenance
Magnetic Resonance Imaging
Motor Cortex
Neuroimaging

Keywords

  • Functional magnetic resonance imaging
  • Healthy adults
  • Load
  • Maintenance

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Altamura, M., Elvevåg, B., Blasi, G., Bertolino, A., Callicott, J. H., Weinberger, D., ... Goldberg, T. E. (2007). Dissociating the effects of Sternberg working memory demands in prefrontal cortex. Psychiatry Research - Neuroimaging, 154(2), 103-114. https://doi.org/10.1016/j.pscychresns.2006.08.002

Dissociating the effects of Sternberg working memory demands in prefrontal cortex. / Altamura, Mario; Elvevåg, Brita; Blasi, Giuseppe; Bertolino, Alessandro; Callicott, Joseph H.; Weinberger, Daniel; Mattay, Venkata; Goldberg, Terry E.

In: Psychiatry Research - Neuroimaging, Vol. 154, No. 2, 28.02.2007, p. 103-114.

Research output: Contribution to journalArticle

Altamura, Mario ; Elvevåg, Brita ; Blasi, Giuseppe ; Bertolino, Alessandro ; Callicott, Joseph H. ; Weinberger, Daniel ; Mattay, Venkata ; Goldberg, Terry E. / Dissociating the effects of Sternberg working memory demands in prefrontal cortex. In: Psychiatry Research - Neuroimaging. 2007 ; Vol. 154, No. 2. pp. 103-114.
@article{197b3abb112f4b15bba680f7965ace26,
title = "Dissociating the effects of Sternberg working memory demands in prefrontal cortex",
abstract = "Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the present functional resonance imaging (fMRI) study was to map within prefrontal cortex locales that are selectively load sensitive, delay sensitive, or both. We studied 18 right-handed normal subjects with fMRI at 3 Tesla during a block design version of the Sternberg task. WM load was manipulated by varying the memory set size (3, 5, or 8 letters). The effect of memory maintenance was examined by employing two time delays (1 s and 6 s) between the letter set and probe stimuli. The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas. Moreover, regions of prefrontal cortex on the right (BA 46) were found to be exclusively affected by load. These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas.",
keywords = "Functional magnetic resonance imaging, Healthy adults, Load, Maintenance",
author = "Mario Altamura and Brita Elvev{\aa}g and Giuseppe Blasi and Alessandro Bertolino and Callicott, {Joseph H.} and Daniel Weinberger and Venkata Mattay and Goldberg, {Terry E.}",
year = "2007",
month = "2",
day = "28",
doi = "10.1016/j.pscychresns.2006.08.002",
language = "English (US)",
volume = "154",
pages = "103--114",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Dissociating the effects of Sternberg working memory demands in prefrontal cortex

AU - Altamura, Mario

AU - Elvevåg, Brita

AU - Blasi, Giuseppe

AU - Bertolino, Alessandro

AU - Callicott, Joseph H.

AU - Weinberger, Daniel

AU - Mattay, Venkata

AU - Goldberg, Terry E.

PY - 2007/2/28

Y1 - 2007/2/28

N2 - Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the present functional resonance imaging (fMRI) study was to map within prefrontal cortex locales that are selectively load sensitive, delay sensitive, or both. We studied 18 right-handed normal subjects with fMRI at 3 Tesla during a block design version of the Sternberg task. WM load was manipulated by varying the memory set size (3, 5, or 8 letters). The effect of memory maintenance was examined by employing two time delays (1 s and 6 s) between the letter set and probe stimuli. The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas. Moreover, regions of prefrontal cortex on the right (BA 46) were found to be exclusively affected by load. These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas.

AB - Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the present functional resonance imaging (fMRI) study was to map within prefrontal cortex locales that are selectively load sensitive, delay sensitive, or both. We studied 18 right-handed normal subjects with fMRI at 3 Tesla during a block design version of the Sternberg task. WM load was manipulated by varying the memory set size (3, 5, or 8 letters). The effect of memory maintenance was examined by employing two time delays (1 s and 6 s) between the letter set and probe stimuli. The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas. Moreover, regions of prefrontal cortex on the right (BA 46) were found to be exclusively affected by load. These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas.

KW - Functional magnetic resonance imaging

KW - Healthy adults

KW - Load

KW - Maintenance

UR - http://www.scopus.com/inward/record.url?scp=33847181739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847181739&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2006.08.002

DO - 10.1016/j.pscychresns.2006.08.002

M3 - Article

C2 - 17292590

AN - SCOPUS:33847181739

VL - 154

SP - 103

EP - 114

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2

ER -