Dissociable neural mechanisms underlying the modulation of pain and anxiety? An fMRI pilot study

Katja Wiech, Robert Edwards, Graham Lorimer Moseley, Chantal Berna, Markus Ploner, Irene Tracey

Research output: Contribution to journalArticle

Abstract

The down-regulation of pain through beliefs is commonly discussed as a form of emotion regulation. In line with this interpretation, the analgesic effect has been shown to co-occur with reduced anxiety and increased activity in the ventrolateral prefrontal cortex (VLPFC), which is a key region of emotion regulation. This link between pain and anxiety modulation raises the question whether the two effects are rooted in the same neural mechanism. In this pilot fMRI study, we compared the neural basis of the analgesic and anxiolytic effect of two types of threat modulation: a "behavioral control" paradigm, which involves the ability to terminate a noxious stimulus, and a "safety signaling" paradigm, which involves visual cues that signal the threat (or absence of threat) that a subsequent noxious stimulus might be of unusually high intensity. Analgesia was paralleled by VLPFC activity during behavioral control. Safety signaling engaged elements of the descending pain control system, including the rostral anterior cingulate cortex that showed increased functional connectivity with the periaqueductal gray and VLPFC. Anxiety reduction, in contrast, scaled with dorsolateral prefrontal cortex activation during behavioral control but had no distinct neural signature during safety signaling. Our pilot data therefore suggest that analgesic and anxiolytic effects are instantiated in distinguishable neural mechanisms and differ between distinct stress- and pain-modulatory approaches, supporting the recent notion of multiple pathways subserving top-down modulation of the pain experience. Additional studies in larger cohorts are needed to follow up on these preliminary findings.

Original languageEnglish (US)
Article numbere110654
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 15 2014
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Wiech, K., Edwards, R., Moseley, G. L., Berna, C., Ploner, M., & Tracey, I. (2014). Dissociable neural mechanisms underlying the modulation of pain and anxiety? An fMRI pilot study. PLoS One, 9(12), [e110654]. https://doi.org/10.1371/journal.pone.0110654