Disseminated mycobacterium avium complex in an immunocompetent host: A case report

Kim A. Reiss; Sophie Lanzkron; Steven M. Holland; Ryan P. Westergaard; William A. Fischer

doi:10.1097/IPC.0b013e318234c3e3

Disseminated mycobacterium avium complex in an immunocompetent host: A case report

Kim A. Reiss, Sophie Lanzkron, Steven M. Holland, Ryan P. Westergaard, William A. Fischer

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.

Original language	English (US)
Pages (from-to)	208-209
Number of pages	2
Journal	Infectious Diseases in Clinical Practice
Volume	20
Issue number	3
DOIs	https://doi.org/10.1097/IPC.0b013e318234c3e3
State	Published - May 1 2012

Keywords

Mycobacterium avium complex
interferon gamma
interleukin 12
sickle cell disease

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1097/IPC.0b013e318234c3e3

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abstract = "Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.",

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AU - Fischer, William A.

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AB - Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.

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KW - interferon gamma

KW - interleukin 12

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Disseminated mycobacterium avium complex in an immunocompetent host: A case report

Abstract

Keywords

ASJC Scopus subject areas

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