Disseminated histoplasmosis and childhood leukemia

F. Cox, W. T. Hughes

Research output: Contribution to journalArticle

Abstract

The course of histoplasmosis in patients with childhood leukemia is poorly understood. Past attempts to characterize the disease have relied on single case reports, without benefit of a series of patients with similar types of leukemia and chemotherapy. Described here are the clinical course of infection, laboratory findings, and therapy in 6 children with acute lymphocytic leukemia and disseminated histoplasmosis. A diagnosis of histoplasmosis was most commonly encountered during remission of the leukemia in patients presenting with fever, hepatosplenomegaly, variable chest roentgenogram findings, leukopenia, and/or neutropenia. Bone marrow cultures revealed the presence of Histoplasma capsulatum in each. All 6 children were treated with amphotericin B and recovered from the infection.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalCancer
Volume33
Issue number4
StatePublished - 1974
Externally publishedYes

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Histoplasmosis
Leukemia
Laboratory Infection
Histoplasma
Leukopenia
Amphotericin B
Neutropenia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fever
Thorax
Bone Marrow
Drug Therapy
Infection
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cox, F., & Hughes, W. T. (1974). Disseminated histoplasmosis and childhood leukemia. Cancer, 33(4), 1127-1133.

Disseminated histoplasmosis and childhood leukemia. / Cox, F.; Hughes, W. T.

In: Cancer, Vol. 33, No. 4, 1974, p. 1127-1133.

Research output: Contribution to journalArticle

Cox, F & Hughes, WT 1974, 'Disseminated histoplasmosis and childhood leukemia', Cancer, vol. 33, no. 4, pp. 1127-1133.
Cox F, Hughes WT. Disseminated histoplasmosis and childhood leukemia. Cancer. 1974;33(4):1127-1133.
Cox, F. ; Hughes, W. T. / Disseminated histoplasmosis and childhood leukemia. In: Cancer. 1974 ; Vol. 33, No. 4. pp. 1127-1133.
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