The course of histoplasmosis in patients with childhood leukemia is poorly understood. Past attempts to characterize the disease have relied on single case reports, without benefit of a series of patients with similar types of leukemia and chemotherapy. Described here are the clinical course of infection, laboratory findings, and therapy in six children with acute lymphocytic leukemia and disseminated histoplasmosis. A diagnosis of histoplasmosis was most commonly encountered during remission of the leukemia in patients presenting with fever, hepatosplenomegaly, variable chest roentgenogram findings, leukopenia, and/or neutropenia. Bone marrow cultures revealed the presence of Histoplasma capsulatum in each. All six children were treated with amphotericin B and recovered from the infection.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Apr 1974|
ASJC Scopus subject areas
- Cancer Research