Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: A case report

Baligh Ramzi Yehia, Michael Eberlein, Stephen D. Sisson, David N. Hager

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Cryptococcus neoformans is an encapsulated yeast that causes serious infections in immunocompromised populations. The majority of cases occur in HIV-infected individuals. Disseminated disease is uncommon, and very rarely includes peritonitis. Case presentation: We report a case of a 41-year-old, HIV-negative, Caucasian man with alcoholic liver cirrhosis who presented with fever and seizure. Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia was diagnosed, and despite adequate treatment the patient developed multi-system organ failure and eventually expired. Conclusion: Disseminated cryptococcosis, particularly with peritonitis, is an uncommon manifestation of Cryptococcus neoformans infection. Liver cirrhosis serves as a risk factor for disseminated disease in HIV-negative patients. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively.

Original languageEnglish (US)
Article number170
JournalCases Journal
Volume2
Issue number10
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Medicine(all)

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