Disseminated cryptococcosis in man: Decreased lymphocyte transformation in response to cryptococcus neoformans

Richard D. Diamond, John E. Bennett

Research output: Contribution to journalArticle

Abstract

Heat-killed Cryptococcus neoformans, a yeast-like fungus, was used to stimulate in-vitro incorporation of thymidine by human lymphocytes. Lymphocytes from control subjects previously exposed to cryptococci (positive skin tests) had significantly higher uptake of thymidine than cells from unexposed control subjects (negative skin tests). Uptake by lymphocytes from successfully treated patients with cryptococcosis was low when compared with that of exposed control subjects. It is suggested that defective function of lymphocytes may reflect increased susceptibility to cryptococcal infection in some patients with cryptococcosis without any other known predisposing factors.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalJournal of Infectious Diseases
Volume127
Issue number6
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Cryptococcosis
Cryptococcus neoformans
Lymphocyte Activation
Lymphocytes
Skin Tests
Thymidine
Cryptococcus
Causality
Fungi
Hot Temperature
Yeasts
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Disseminated cryptococcosis in man : Decreased lymphocyte transformation in response to cryptococcus neoformans. / Diamond, Richard D.; Bennett, John E.

In: Journal of Infectious Diseases, Vol. 127, No. 6, 1973, p. 694-697.

Research output: Contribution to journalArticle

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