Disseminated cryptococcosis in an HIV-negative pregnancy: a case of cryptococcal septic abortion complicating an immunocompetent pregnancy

Sravani V. Mudumbi

Research output: Contribution to journalArticle

Abstract

Cryptococcus neoformans, a well-known pathogen of the immunocompromised host, is rarely reported as a cause of disseminated infection in the immunocompetent pregnant woman. Reported herein is the case of a young gravid woman, who initially presented with vague systemic symptoms that evolved into a disseminated cryptococcosis, which was resistant to standard parenteral antifungal therapy and resulted in abortion. Experience from this case suggests that cryptococcal infection should be considered in the differential diagnosis of pregnant women presenting with vague systemic symptoms such as fever, abdominal pain, and generalized lymphadenopathy.

Original languageEnglish (US)
JournalInternational Journal of Infectious Diseases
Volume14
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Septic Abortion
Cryptococcosis
Pregnant Women
HIV
Pregnancy
Cryptococcus neoformans
Immunocompromised Host
Infection
Abdominal Pain
Differential Diagnosis
Fever
Therapeutics

Keywords

  • Cryptococcus
  • Disseminated
  • HIV-negative
  • Immunocompetent
  • Pregnancy
  • Septic abortion

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

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AB - Cryptococcus neoformans, a well-known pathogen of the immunocompromised host, is rarely reported as a cause of disseminated infection in the immunocompetent pregnant woman. Reported herein is the case of a young gravid woman, who initially presented with vague systemic symptoms that evolved into a disseminated cryptococcosis, which was resistant to standard parenteral antifungal therapy and resulted in abortion. Experience from this case suggests that cryptococcal infection should be considered in the differential diagnosis of pregnant women presenting with vague systemic symptoms such as fever, abdominal pain, and generalized lymphadenopathy.

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