Disseminated calcitonin-poor medullary thyroid carcinoma in a patient with calcitonin-rich primary tumor

J. M. Ruppert, J. C. Eggleston, A. DeBustros, Stephen B Baylin

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A multiple endocrine neoplasia type Ia patient who initially had a calcitonin-rich medullary thyroid carcinoma followed an indolent clinical course for 7 years after surgical resection. Sudden rapid dissemination of tumor led to death 2 years later. At autopsy, calcitonin immunostaining of tumor was diffusely negative, with slight positivity in less than 5% of cells. The loss of a marker of differentiation in association with the marked change in the clinical course suggests the development within the well-differentiated tumor of a poorly differentiated, biologically aggressive population of tumor cells.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalAmerican Journal of Surgical Pathology
Issue number7
StatePublished - 1986


ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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