Abstract
A multiple endocrine neoplasia type Ia patient who initially had a calcitonin-rich medullary thyroid carcinoma followed an indolent clinical course for 7 years after surgical resection. Sudden rapid dissemination of tumor led to death 2 years later. At autopsy, calcitonin immunostaining of tumor was diffusely negative, with slight positivity in less than 5% of cells. The loss of a marker of differentiation in association with the marked change in the clinical course suggests the development within the well-differentiated tumor of a poorly differentiated, biologically aggressive population of tumor cells.
Original language | English (US) |
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Pages (from-to) | 513-518 |
Number of pages | 6 |
Journal | American Journal of Surgical Pathology |
Volume | 10 |
Issue number | 7 |
DOIs | |
State | Published - 1986 |
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine