Disseminated Bacillus Calmette-Guérin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II

R. F. Abu-Arja, B. E. Gonzalez, M. R. Jacobs, L. Cabral, R. Egler, J. Auletta, J. Arnold, K. R. Cooke

Research output: Contribution to journalArticle

Abstract

We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Guérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.

Original languageEnglish (US)
Pages (from-to)830-837
Number of pages8
JournalTransplant Infectious Disease
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2014

    Fingerprint

Keywords

  • BCG infection
  • Bare Lymphocyte Syndrome II
  • HSCT
  • Mycobacterium bovis
  • Pediatric transplant

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

Cite this