Disseminated Bacillus Calmette-Guérin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II

R. F. Abu-Arja; B. E. Gonzalez; M. R. Jacobs; L. Cabral; R. Egler; J. Auletta; J. Arnold; K. R. Cooke

doi:10.1111/tid.12263

Disseminated Bacillus Calmette-Guérin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II

R. F. Abu-Arja, B. E. Gonzalez, M. R. Jacobs, L. Cabral, R. Egler, J. Auletta, J. Arnold, K. R. Cooke

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Guérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.

Original language	English (US)
Pages (from-to)	830-837
Number of pages	8
Journal	Transplant Infectious Disease
Volume	16
Issue number	5
DOIs	https://doi.org/10.1111/tid.12263
State	Published - Oct 1 2014

Keywords

BCG infection
Bare Lymphocyte Syndrome II
HSCT
Mycobacterium bovis
Pediatric transplant

ASJC Scopus subject areas

Infectious Diseases
Transplantation

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10.1111/tid.12263

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title = "Disseminated Bacillus Calmette-Gu{\'e}rin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II",

abstract = "We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Gu{\'e}rin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.",

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AU - Jacobs, M. R.

AU - Cabral, L.

AU - Egler, R.

AU - Auletta, J.

AU - Arnold, J.

AU - Cooke, K. R.

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AB - We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Guérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.

KW - BCG infection

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Disseminated Bacillus Calmette-Guérin (BCG) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II

Abstract

Keywords

ASJC Scopus subject areas

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