Disseminated Aspergillosis Complicating Hepatic Failure

Thomas J. Walsh, Stanley R. Hamilton

Research output: Contribution to journalArticle

Abstract

Disseminated aspergillosis is not generally known as a complication of hepatic failure. Three patients with subacute hepatic necrosis died of clinically unrecognized disseminated aspergillosis. All of the patients had pulmonary aspergillosis and Aspergillus infections of the CNS. Focal neurologic deficits were clinically misconstrued as intracerebral hemorrhages caused by the coagulopathy of liver failure. Signs of invasive pulmonary aspergillosis were ascribed to refractory bacterial pneumonia. Each patient had a hospital course of longer than three weeks and each received treatment with corticosteroids and intravenous antibiotics. Invasive aspergillosis should be considered as a cause of refractory pneumonia and of new focal neurologic deficits in patients with hepatic failure.

Original languageEnglish (US)
Pages (from-to)1189-1191
Number of pages3
JournalArchives of Internal Medicine
Volume143
Issue number6
DOIs
StatePublished - 1983

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Aspergillosis
Liver Failure
Neurologic Manifestations
Invasive Pulmonary Aspergillosis
Pulmonary Aspergillosis
Bacterial Pneumonia
Cerebral Hemorrhage
Aspergillus
Pneumonia
Adrenal Cortex Hormones
Necrosis
Anti-Bacterial Agents
Liver
Infection
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Disseminated Aspergillosis Complicating Hepatic Failure. / Walsh, Thomas J.; Hamilton, Stanley R.

In: Archives of Internal Medicine, Vol. 143, No. 6, 1983, p. 1189-1191.

Research output: Contribution to journalArticle

Walsh, Thomas J. ; Hamilton, Stanley R. / Disseminated Aspergillosis Complicating Hepatic Failure. In: Archives of Internal Medicine. 1983 ; Vol. 143, No. 6. pp. 1189-1191.
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