Disseminate cryptococcosis in a guenon (Cercopithecus ascanius)

K. L. Helke, M. C. Denver, E. Bronson, J. L. Mankowski

Research output: Contribution to journalArticlepeer-review

Abstract

A 23-year-old captive-bred red-tailed guenon (Cercopithecus ascanius) with a brief history of inappetence, lethargy, and seizures was submitted for necropsy. On postmortem examination, multiple cryptococcomas were identified in brain and heart. Cryptococcus neoformans organisms were also identified microscopically in kidney, eye, and pancreas. Fungal yeast formed rare pseudohyphae. The histologic diagnosis of cryptococcosis was confirmed by a positive test for C. neoformans antigen in a serum sample. Immunohistochemical staining confirmed that macrophages were the principal inflammatory cell in brain lesions and often contained phagocytosed yeast. As disseminate cryptococcosis is often associated with immune suppression, serology and immunohistochemical staining for simian immunodeficiency virus were performed but showed no evidence of SIV infection.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalVeterinary pathology
Volume43
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Brain
  • Cryptococcus
  • Guenon
  • Heart
  • Primate

ASJC Scopus subject areas

  • veterinary(all)

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