Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice

Yi Tang, Varalakshmi Katuri, Allan Dillner, Bibhuti Mishra, Chu Xia Deng, Lopa Mishra

Research output: Contribution to journalArticlepeer-review

Abstract

Disruption of the adaptor protein ELF, a β-spectrin, leads to disruption of transforming growth factor-β (TGF-β) signaling by Smad proteins in mice. Elf-/- mice exhibit a phenotype similar to smad2+/-/smad3+/- mutant mice of midgestational death due to gastrointestinal, liver, neural, and heart defects. We show that TGF-β triggers phosphorylation and association of ELF with Smad3 and Smad4, followed by nuclear translocation. ELF deficiency results in mislocalization of Smad3 and Smad4 and loss of the TGF-β-dependent transcriptional response, which could be rescued by overexpression of the COOH-terminal region of ELF. This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway.

Original languageEnglish (US)
Pages (from-to)574-577
Number of pages4
JournalScience
Volume299
Issue number5606
DOIs
StatePublished - Jan 24 2003

ASJC Scopus subject areas

  • General

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