Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier. The tracer penetrated the cytoplasm of the endothelial cells and retinal pigment epithelial cells in areas that showed extravasation of the tracer into the interstitial space of the retina. Cell junctions, however, between endothelial cells or between retinal pigment epithelial cells were intact. It is believed that subtle impairments of the plasmalemmas of the endothelial cells and RPE cells were responsible for the focal disturbances of the blood-retinal barrier in this model.
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience