Disruption of blood-retinal barrier in ocular hypotony: Preliminary report

Mark O.M. Tso; C. Y. Shih

doi:10.1016/0014-4835(76)90204-9

Disruption of blood-retinal barrier in ocular hypotony: Preliminary report

Mark O.M. Tso, C. Y. Shih

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier. The tracer penetrated the cytoplasm of the endothelial cells and retinal pigment epithelial cells in areas that showed extravasation of the tracer into the interstitial space of the retina. Cell junctions, however, between endothelial cells or between retinal pigment epithelial cells were intact. It is believed that subtle impairments of the plasmalemmas of the endothelial cells and RPE cells were responsible for the focal disturbances of the blood-retinal barrier in this model.

Original language	English (US)
Pages (from-to)	209-216
Number of pages	8
Journal	Experimental eye research
Volume	23
Issue number	2 PART 2
DOIs	https://doi.org/10.1016/0014-4835(76)90204-9
State	Published - Aug 1976

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(76)90204-9

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title = "Disruption of blood-retinal barrier in ocular hypotony: Preliminary report",

abstract = "Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier. The tracer penetrated the cytoplasm of the endothelial cells and retinal pigment epithelial cells in areas that showed extravasation of the tracer into the interstitial space of the retina. Cell junctions, however, between endothelial cells or between retinal pigment epithelial cells were intact. It is believed that subtle impairments of the plasmalemmas of the endothelial cells and RPE cells were responsible for the focal disturbances of the blood-retinal barrier in this model.",

author = "Tso, {Mark O.M.} and Shih, {C. Y.}",

note = "Funding Information: This study was supported in part by h{\textquoteright}ational Institutes of Health Research Grant EY 01163 and by Tmining Gmnt EY 00032 from the National Eye Institute, I{\textquoteright}HS/ DHEW. The opinions and a,ssertions contained herein are the private views of the authors and are not to be construed as official nor as reflecting the views of the Department of the Army or the Department of Defense. In conducting the research described in this report,, the investigators adhered to the “Guide for Laboratory Animal Facilities and Care”, as promulgated by the Committee on the Guide for Laboratory Snimal Facilities and Care of the Institute of Laboratory Animal Resources, National gcademy of Sciences-Xational Research Councii. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1976",

month = aug,

doi = "10.1016/0014-4835(76)90204-9",

language = "English (US)",

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pages = "209--216",

journal = "Experimental Eye Research",

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AU - Tso, Mark O.M.

AU - Shih, C. Y.

N1 - Funding Information: This study was supported in part by h’ational Institutes of Health Research Grant EY 01163 and by Tmining Gmnt EY 00032 from the National Eye Institute, I’HS/ DHEW. The opinions and a,ssertions contained herein are the private views of the authors and are not to be construed as official nor as reflecting the views of the Department of the Army or the Department of Defense. In conducting the research described in this report,, the investigators adhered to the “Guide for Laboratory Animal Facilities and Care”, as promulgated by the Committee on the Guide for Laboratory Snimal Facilities and Care of the Institute of Laboratory Animal Resources, National gcademy of Sciences-Xational Research Councii. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1976/8

Y1 - 1976/8

N2 - Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier. The tracer penetrated the cytoplasm of the endothelial cells and retinal pigment epithelial cells in areas that showed extravasation of the tracer into the interstitial space of the retina. Cell junctions, however, between endothelial cells or between retinal pigment epithelial cells were intact. It is believed that subtle impairments of the plasmalemmas of the endothelial cells and RPE cells were responsible for the focal disturbances of the blood-retinal barrier in this model.

AB - Disruption of blood-retinal barrier at the levels of retinal vasculature and the retinal pigment epithelium was observed in rhesus monkeys subjected to prolonged ocular hypotony after application of cryotherapy to the ciliary body. Horseradish peroxidase was employed as a tracer for the disruption of the blood-retinal barrier. The tracer penetrated the cytoplasm of the endothelial cells and retinal pigment epithelial cells in areas that showed extravasation of the tracer into the interstitial space of the retina. Cell junctions, however, between endothelial cells or between retinal pigment epithelial cells were intact. It is believed that subtle impairments of the plasmalemmas of the endothelial cells and RPE cells were responsible for the focal disturbances of the blood-retinal barrier in this model.

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ER -

Disruption of blood-retinal barrier in ocular hypotony: Preliminary report

Abstract

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