Disrupting the ventral premotor cortex interferes with the contribution of action observation to use-dependent plasticity

Gabriela Cantarero, Joseph M. Galea, Loni Ajagbe, Rachel Salas, Jeff Willis, Pablo A Celnik

Research output: Contribution to journalArticle

Abstract

Action observation (AO), observing another individual perform an action, has been implicated in several higher cognitive processes including forming basic motor memories. Previous work has shown that physical practice (PP) results in cortical motor representational changes, referred to as use-dependent plasticity (UDP), and that AO combined with PP potentiates UDP in both healthy adults and stroke patients. In humans, AO results in activation of the ventral premotor cortex (PMv), however, whether this PMv activation has a functional contribution to UDP is not known. Here, we studied the effects disruption of PMv has on UDP when subjects performed PP combined with AO(PP+AO). Subjects participated in two randomized crossover sessions measuring the amount of UDP resulting from PP + AO while receiving disruptive (1 Hz) TMS over the fMRI-activated PMv or over frontal cortex (Sham). We found that, unlike the sham session, disruptive TMS over PMv reduced the beneficial contribution of AO to UDP. To ensure that disruption of PMv was specifically interfering with the contribution of AO and not PP, subjects completed two more control sessions where they performed only PP while receiving disruptive TMS over PMv or frontal cortex. We found that the magnitude of UDP for both control sessions was similar to PP+AO with TMS over PMv. These findings suggest that the fMRI activation found in PMv during AO studies is functionally relevant to task performance, at least for the beneficial effects that AO exerts overmotor training.

Original languageEnglish (US)
Pages (from-to)3757-3766
Number of pages10
JournalJournal of Cognitive Neuroscience
Volume23
Issue number12
DOIs
StatePublished - Dec 2011

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Motor Cortex
Observation
activation
Frontal Lobe
Plasticity
Cortex
Magnetic Resonance Imaging
Practice (Psychology)
Physical
Task Performance and Analysis
stroke
Stroke

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Language and Linguistics
  • Linguistics and Language

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Disrupting the ventral premotor cortex interferes with the contribution of action observation to use-dependent plasticity. / Cantarero, Gabriela; Galea, Joseph M.; Ajagbe, Loni; Salas, Rachel; Willis, Jeff; Celnik, Pablo A.

In: Journal of Cognitive Neuroscience, Vol. 23, No. 12, 12.2011, p. 3757-3766.

Research output: Contribution to journalArticle

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