TY - JOUR
T1 - Disrupted intrinsic connectivity of the periaqueductal gray in patients with functional dyspepsia
T2 - A resting-state fMRI study
AU - Liu, P.
AU - Wang, G.
AU - Liu, Y.
AU - Zeng, F.
AU - Lin, D.
AU - Yang, X.
AU - Liang, F.
AU - Calhoun, V. D.
AU - Qin, W.
N1 - Funding Information:
This study was financially supported by the National Natural Science Foundation of China (NSFC; 81471738, 81271644, 81471811 61401346 and 81473602), National Basic Research Program of China (2014CB543203, 2015CB856403, and 2012CB518501), and the Fundamental Research Funds for the Central Universities (NIH 1R01EB006841, R01EB005846, and P20GM103472).
Publisher Copyright:
© 2017 John Wiley & Sons Ltd
PY - 2017/8
Y1 - 2017/8
N2 - Background: Functional dyspepsia (FD) is a common functional gastrointestinal disorder. Accumulating evidence suggests the crucial role of central nervous system in the development and maintenance of FD. In particular, periaqueductal gray (PAG) has demonstrated an important role in modulation of pain and emotion, which may be related to FD. However, the study of the PAG in FD is still limited. This study aimed to assess intrinsic connectivity of the PAG in FD patients. Methods: Resting-state functional magnetic imaging (fMRI) data were collected from 66 FD patients and 42 healthy controls (HCs). Functional connectivity analysis was performed to investigate the PAG connectivity pattern differences between the patients and HCs. We then examined the relationships between functional connectivity within the PAG networks and FD symptoms. Key Results: Compared to HCs, patients had increased PAG connectivity with the insula, and decreased PAG connectivity with the orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (dlPFC) and hippocampus/parahippocampus (HIPP/paraHIPP). There were positive correlations between disease duration and PAG connectivity with the putamen and supplementary motor area (SMA), and positive correlations between symptom severity and PAG connectivity with the insula. FD patients with high level of anxiety and depression had altered PAG connectivity with the anterior cingulate cortex (ACC), precuneus, dlPFC and caudate, compared to other patients. Conclusions & Inferences: These findings indicate that abnormal intrinsic network of the PAG might be associated with abnormality of pain processing and disruption of emotion processing in FD patients. Our study further complements neuroimaging findings about FD.
AB - Background: Functional dyspepsia (FD) is a common functional gastrointestinal disorder. Accumulating evidence suggests the crucial role of central nervous system in the development and maintenance of FD. In particular, periaqueductal gray (PAG) has demonstrated an important role in modulation of pain and emotion, which may be related to FD. However, the study of the PAG in FD is still limited. This study aimed to assess intrinsic connectivity of the PAG in FD patients. Methods: Resting-state functional magnetic imaging (fMRI) data were collected from 66 FD patients and 42 healthy controls (HCs). Functional connectivity analysis was performed to investigate the PAG connectivity pattern differences between the patients and HCs. We then examined the relationships between functional connectivity within the PAG networks and FD symptoms. Key Results: Compared to HCs, patients had increased PAG connectivity with the insula, and decreased PAG connectivity with the orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (dlPFC) and hippocampus/parahippocampus (HIPP/paraHIPP). There were positive correlations between disease duration and PAG connectivity with the putamen and supplementary motor area (SMA), and positive correlations between symptom severity and PAG connectivity with the insula. FD patients with high level of anxiety and depression had altered PAG connectivity with the anterior cingulate cortex (ACC), precuneus, dlPFC and caudate, compared to other patients. Conclusions & Inferences: These findings indicate that abnormal intrinsic network of the PAG might be associated with abnormality of pain processing and disruption of emotion processing in FD patients. Our study further complements neuroimaging findings about FD.
KW - fMRI
KW - functional dyspepsia
KW - intrinsic connectivity
KW - periaqueductal gray
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U2 - 10.1111/nmo.13060
DO - 10.1111/nmo.13060
M3 - Article
C2 - 28338267
AN - SCOPUS:85016435321
VL - 29
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
SN - 1350-1925
IS - 8
M1 - e13060
ER -