Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension

Stephen Mathai, M. Bueso, Laura Hummers, D. Boyce, Noah Lechtzin, J. Le Pavec, A. Campo, H. C. Champion, T. Housten, P. R. Forfia, A. L. Zaiman, Fredrick Wigley, R. E. Girgis, Paul M Hassoun

Research output: Contribution to journalArticle

Abstract

N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of neurohormonal activation that is useful in the diagnosis and prognosis of various forms of pulmonary arterial hypertension (PAH). We sought to characterise and compare NT-proBNP in a cohort of PAH related to systemic sclerosis (PAH-SSc) and idiopathic PAH (IPAH) patients. NT-proBNP levels, collected from PAH-SSc and IPAH patients followed prospectively, were compared and correlated with haemodynamic variables. Cox proportional hazard models were created to assess the predictive value of NT-proBNP. 98 patients (55 PAH-SSc, 43 IPAH) were included. Haemodynamics were similar, except for lower mean pulmonary arterial pressure in PAH-SSc. NT-proBNP levels were significantly higher in PAH-SSc (3,419±3,784 versus 1,393±1,633 pg?mL -1; p

Original languageEnglish (US)
Pages (from-to)95-104
Number of pages10
JournalEuropean Respiratory Journal
Volume35
Issue number1
DOIs
StatePublished - Jan 2010

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Brain Natriuretic Peptide
Pulmonary Hypertension
Hemodynamics
Systemic Scleroderma
Proportional Hazards Models
Arterial Pressure
Lung
Familial Primary Pulmonary Hypertension

Keywords

  • Prognostic markers
  • Pulmonary hypertension
  • Scleroderma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension. / Mathai, Stephen; Bueso, M.; Hummers, Laura; Boyce, D.; Lechtzin, Noah; Le Pavec, J.; Campo, A.; Champion, H. C.; Housten, T.; Forfia, P. R.; Zaiman, A. L.; Wigley, Fredrick; Girgis, R. E.; Hassoun, Paul M.

In: European Respiratory Journal, Vol. 35, No. 1, 01.2010, p. 95-104.

Research output: Contribution to journalArticle

Mathai, Stephen ; Bueso, M. ; Hummers, Laura ; Boyce, D. ; Lechtzin, Noah ; Le Pavec, J. ; Campo, A. ; Champion, H. C. ; Housten, T. ; Forfia, P. R. ; Zaiman, A. L. ; Wigley, Fredrick ; Girgis, R. E. ; Hassoun, Paul M. / Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension. In: European Respiratory Journal. 2010 ; Vol. 35, No. 1. pp. 95-104.
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