Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs

Peyton Jacob, Neal L. Benowitz, James R. Copeland, Marcus E. Risner, Edward J. Cone

Research output: Contribution to journalArticle

Abstract

The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)‐nicotine was similar to that of (S)‐nicotine, but clearance of (R)‐cotinine was twice that of (S)‐cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were ∼50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)‐nicotine was slightly greater than the clearance of (S)‐nicotine. Methods for the synthesis of (R)‐nicotine and (R)‐cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.

Original languageEnglish (US)
Pages (from-to)396-400
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume77
Issue number5
DOIs
StatePublished - May 1988

ASJC Scopus subject areas

  • Pharmaceutical Science

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