Disorders of the hypothalamic-pituitary-thyroid axis

Aniket Sidhaye, Fredric E. Wondisford

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews disorders that are not primarily related to thyroid gland pathology. Thyroid hormone synthesis and secretion is stimulated by the action of thyrotropin (TSH), which is secreted into the general circulation from the anterior pituitary thyrotrope cells. Thyrotropin (TSH) is a member of the glycoprotein hormone family, which includes luteinizing hormone (LH), follicle-stimulating hormone (FSH) and human chorionic gonadotropin (hCG). Hyperthyroxinemia in the setting of a nonsuppressed TSH level is secondary to two different clinical disorders that include resistance to thyroid hormone (RTH) and TSH-secreting pituitary adenoma (TSHoma). The cause of RTH is a germline defect, and as such there is no cure for this condition. As many patients are clinically euthyroid, those compensated patients without symptoms do not require any treatment. TSH-secreting pituitary adenoma is a rare tumor of the anterior pituitary. Nearly three-quarters of all TSHomas secrete only TSH. Patients with hypopituitarism have decreased quality of life, despite replacement hormonal therapy.

Original languageEnglish (US)
Title of host publicationHandbook of Neuroendocrinology
PublisherElsevier Inc.
Pages685-706
Number of pages22
ISBN (Print)9780123750976
DOIs
StatePublished - 2012

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Pituitary Diseases
Pituitary Neoplasms
Thyroid Hormone Resistance Syndrome
Thyroid Gland
Thyrotropin
Hyperthyroxinemia
Hypopituitarism
Follicle Stimulating Hormone
Chorionic Gonadotropin
Luteinizing Hormone
Thyroid Hormones
Glycoproteins
Quality of Life
Hormones
Pathology
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sidhaye, A., & Wondisford, F. E. (2012). Disorders of the hypothalamic-pituitary-thyroid axis. In Handbook of Neuroendocrinology (pp. 685-706). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-375097-6.10031-9

Disorders of the hypothalamic-pituitary-thyroid axis. / Sidhaye, Aniket; Wondisford, Fredric E.

Handbook of Neuroendocrinology. Elsevier Inc., 2012. p. 685-706.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sidhaye, A & Wondisford, FE 2012, Disorders of the hypothalamic-pituitary-thyroid axis. in Handbook of Neuroendocrinology. Elsevier Inc., pp. 685-706. https://doi.org/10.1016/B978-0-12-375097-6.10031-9
Sidhaye A, Wondisford FE. Disorders of the hypothalamic-pituitary-thyroid axis. In Handbook of Neuroendocrinology. Elsevier Inc. 2012. p. 685-706 https://doi.org/10.1016/B978-0-12-375097-6.10031-9
Sidhaye, Aniket ; Wondisford, Fredric E. / Disorders of the hypothalamic-pituitary-thyroid axis. Handbook of Neuroendocrinology. Elsevier Inc., 2012. pp. 685-706
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