Abstract
In recent years, advances in defining the precise molecular defects in both acquired and inherited hypo and hyperphosphatemic syndromes have catapulted our understanding of phosphate homeostatic mechanisms to a new level. The focus of this chapter is the molecular basis of human disorders of phosphate homeostasis. The disorders discussed include hypophosphatemia, tumor-induced osteomalacia (TIO), X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets (ADHR), hyperphosphatemia, and hyperphosphatemic familial tumoral calcinosis (HFTC). Other disorders of renal phosphate wasting are also considered.
| Original language | English (US) |
|---|---|
| Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition |
| Publisher | Wiley Blackwell |
| Pages | 601-612 |
| Number of pages | 12 |
| ISBN (Electronic) | 9781118453926 |
| ISBN (Print) | 9781118453889 |
| DOIs | |
| State | Published - Jul 19 2013 |
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Keywords
- Autosomal dominant hypophosphatemic rickets
- Familial tumoral calcinosis
- Hyperphosphatemia
- Hypophosphatemia
- Phosphate homeostasis
- Renal phosphate wasting
- Tumor-induced osteomalacia (TIO)
- X-linked hypophosphatemic rickets
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Disorders of Phosphate Homeostasis. / Ruppe, Mary D.; Jan De Beur, Suzanne M.
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, 2013. p. 601-612.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Disorders of Phosphate Homeostasis
AU - Ruppe, Mary D.
AU - Jan De Beur, Suzanne M
PY - 2013/7/19
Y1 - 2013/7/19
N2 - In recent years, advances in defining the precise molecular defects in both acquired and inherited hypo and hyperphosphatemic syndromes have catapulted our understanding of phosphate homeostatic mechanisms to a new level. The focus of this chapter is the molecular basis of human disorders of phosphate homeostasis. The disorders discussed include hypophosphatemia, tumor-induced osteomalacia (TIO), X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets (ADHR), hyperphosphatemia, and hyperphosphatemic familial tumoral calcinosis (HFTC). Other disorders of renal phosphate wasting are also considered.
AB - In recent years, advances in defining the precise molecular defects in both acquired and inherited hypo and hyperphosphatemic syndromes have catapulted our understanding of phosphate homeostatic mechanisms to a new level. The focus of this chapter is the molecular basis of human disorders of phosphate homeostasis. The disorders discussed include hypophosphatemia, tumor-induced osteomalacia (TIO), X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets (ADHR), hyperphosphatemia, and hyperphosphatemic familial tumoral calcinosis (HFTC). Other disorders of renal phosphate wasting are also considered.
KW - Autosomal dominant hypophosphatemic rickets
KW - Familial tumoral calcinosis
KW - Hyperphosphatemia
KW - Hypophosphatemia
KW - Phosphate homeostasis
KW - Renal phosphate wasting
KW - Tumor-induced osteomalacia (TIO)
KW - X-linked hypophosphatemic rickets
UR - http://www.scopus.com/inward/record.url?scp=85015035599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015035599&partnerID=8YFLogxK
U2 - 10.1002/9781118453926.ch74
DO - 10.1002/9781118453926.ch74
M3 - Chapter
AN - SCOPUS:85015035599
SN - 9781118453889
SP - 601
EP - 612
BT - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition
PB - Wiley Blackwell
ER -