Diseases of the retinal pigment epithelium

I. H. Maumenee, M. A. Del Monte

Research output: Contribution to journalArticlepeer-review


Very little is known about the biochemistry of the normal human pigment epithelium. This is in large proportion due to the fact that is is present in small quantities in each eye only. It is only one cell layer thick making acquisition of significant amounts of tissue from a single human eye difficult, and thus a biochemical study impossible. In addition, the rod outer segments and the pigment epithelium are so closely associated in vivo that specimens of one layer are invariably contaminated with the other. Thus, the biochemical study of in vitro cell cultures seems the plausible approach to biochemical study of this tissue. We therefore elected to study the tissue culture behavior of the normal human retinal pigment epithelium, to be prepared for study of eyes with true retinitis pigmentosa as they become available.

Original languageEnglish (US)
Pages (from-to)315-326
Number of pages12
JournalBirth Defects: Original Article Series
Issue number2
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

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