Disease severity and health-related quality of life across difference chronic conditions

L. Ferrucci, S. Baldasseroni, S. Bandinelli, W. De Alfieri, A. Cartei, D. Calvani, A. Baldini, G. Masotti, N. Marchionni

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


OBJECTIVES: Measurements of health-related quality of life (HRQL) are an essential component in overall assessment of health status, particularly in older patients. Nevertheless, how measures of HRQL relate to measures of disease severity is largely unexplored. This study was carried out to explore the relationship between a measure of HRQL and measures of severity of ischemic stroke, Parkinson's diseases (PD), or chronic coronary heart disease (CHD). DESIGN AND SETTING: Cross-sectional analysis of three groups (54 subjects each) of patients aged ≥ 65 years consecutively referred to outpatient clinics for stroke, PD, or CHD, excluding those with cognitive impairment and severe comorbidity. MEASUREMENTS: Severity of stroke, PD, and CHD assessed by Fugl-Meyer Scale (FMS), Webster Rating Scale (WBRS), and total work capacity (TWC, from graded exercise test), respectively. HRQL was determined by the Sickness Impact Profile (SIP). RESULTS: In PD, WBRS correlated linearly with SIP global score, whereas a significant linear relationship between measures of disease severity and SIP score was limited to the least severely diseased stroke (FMS score>160) and the most severely diseased CHD (TWC

Original languageEnglish (US)
Pages (from-to)1490-1495
Number of pages6
JournalJournal of the American Geriatrics Society
Issue number11
StatePublished - 2000
Externally publishedYes


  • Comorbidity
  • Disability
  • Older adults
  • Quality of life

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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