Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma

Andrew W. Joseph, Theresa Guo, Kevin Hur, Yanjun Xie, Linda Yin, Joseph A. Califano, Patrick K. Ha, Harry Quon, Jeremy D. Richmon, David W. Eisele, Nishant Agrawal, Carole Fakhry

Research output: Contribution to journalArticle

Abstract

Background Factors associated with disease-free survival (DFS) after salvage therapy for recurrent oropharyngeal squamous cell carcinoma (SCC) in the context of human papillomavirus (HPV) are poorly understood. Methods A retrospective cohort analysis was conducted of patients with recurrent oropharyngeal SCC with known HPV tumor status who received salvage therapy. Results Eighty-six patients were eligible for analysis. Sixty-four patients (74%) were HPV-positive. In multivariable analysis, HPV-positive tumor status (hazard ratio [HR] = 0.30; 95% confidence interval [CI] = 0.13-0.71; p =.007), clinical response to any salvage therapy (HR = 0.29; 95% CI = 0.11-0.77; p =.01), and surgical salvage (HR = 0.38; 95% CI = 0.16-0.88; p =.02) were associated with improved overall survival (OS). Positive surgical margin was associated with worse DFS after salvage (HR = 8.43; 95% CI = 1.99-35.70; p =.004). Conclusion For recurrent oropharyngeal SCC, HPV-positive tumor status, surgical salvage, and clinical response to salvage therapy are independently associated with improved OS, but not DFS after salvage. Surgical margin is the only independent predictor of DFS.

Original languageEnglish (US)
Pages (from-to)E1501-E1509
JournalHead and Neck
Volume38
DOIs
StatePublished - Apr 1 2016

Keywords

  • head and neck cancer
  • human papillomavirus
  • oropharyngeal cancer
  • salvage therapy
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Joseph, A. W., Guo, T., Hur, K., Xie, Y., Yin, L., Califano, J. A., Ha, P. K., Quon, H., Richmon, J. D., Eisele, D. W., Agrawal, N., & Fakhry, C. (2016). Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head and Neck, 38, E1501-E1509. https://doi.org/10.1002/hed.24268