TY - JOUR
T1 - DISCRIMINATIVE STIMULUS EFFECTS OF DIAZEPAM AND BUSPIRONE IN NORMAL VOLUNTEERS
AU - Rush, Craig R.
AU - Critchfield, Thomas S.
AU - Troisi, Joseph R.
AU - Griffiths, Roland R.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/5
Y1 - 1995/5
N2 - A within‐subject design was used to characterize the effects of dose manipulations on discriminative and self‐reported effects of oral diazepam and buspirone. Subjects were trained to discriminate diazepam (10 mg) versus placebo (n = 10), or buspirone (10 or 15 mg) versus placebo (n = 9). The compounds were identified to subjects by letter code before discrimination training began. In later sessions, correct identifications at 2 hr after the oral administration of drug earned money. All subjects showed accurate discrimination performance during the test‐of‐acquisition phase. In a low‐dose generalization phase, diazepam and buspirone produced dose‐related increases in drug identifications across a four‐fold range of doses. In a subsequent low‐dose training phase, in which subjects were trained to discriminate progressively lower drug doses, the median lowest discriminable dose of diazepam and buspirone was 2.5 and 7.5 mg, respectively. Dose‐response functions for drug identifications were shifted leftward in the low‐dose training phase relative to the low‐dose generalization phase, suggesting that reinforcement of progressively lower doses enhances drug discriminability. The self‐reported effects of diazepam and buspirone were similar (e.g., both drugs increased ratings of drug strength and clumsy/uncoordinated) and different (e.g., diazepam but not buspirone increased ratings of drowsy/sleepy; buspirone but not diazepam increased ratings of tense/nervous). This study demonstrates discriminative and self‐reported effects of diazepam and buspirone at doses lower than previously shown to be behaviorally active, and suggests that at commonly used clinical doses, diazepam is relatively more discriminable than buspirone. 1995 Society for the Experimental Analysis of Behavior
AB - A within‐subject design was used to characterize the effects of dose manipulations on discriminative and self‐reported effects of oral diazepam and buspirone. Subjects were trained to discriminate diazepam (10 mg) versus placebo (n = 10), or buspirone (10 or 15 mg) versus placebo (n = 9). The compounds were identified to subjects by letter code before discrimination training began. In later sessions, correct identifications at 2 hr after the oral administration of drug earned money. All subjects showed accurate discrimination performance during the test‐of‐acquisition phase. In a low‐dose generalization phase, diazepam and buspirone produced dose‐related increases in drug identifications across a four‐fold range of doses. In a subsequent low‐dose training phase, in which subjects were trained to discriminate progressively lower drug doses, the median lowest discriminable dose of diazepam and buspirone was 2.5 and 7.5 mg, respectively. Dose‐response functions for drug identifications were shifted leftward in the low‐dose training phase relative to the low‐dose generalization phase, suggesting that reinforcement of progressively lower doses enhances drug discriminability. The self‐reported effects of diazepam and buspirone were similar (e.g., both drugs increased ratings of drug strength and clumsy/uncoordinated) and different (e.g., diazepam but not buspirone increased ratings of drowsy/sleepy; buspirone but not diazepam increased ratings of tense/nervous). This study demonstrates discriminative and self‐reported effects of diazepam and buspirone at doses lower than previously shown to be behaviorally active, and suggests that at commonly used clinical doses, diazepam is relatively more discriminable than buspirone. 1995 Society for the Experimental Analysis of Behavior
KW - anxiolytics
KW - behavioral pharmacology
KW - buspirone
KW - diazepam
KW - drug discrimination
KW - humans
KW - self‐reported effects
UR - http://www.scopus.com/inward/record.url?scp=0029299279&partnerID=8YFLogxK
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U2 - 10.1901/jeab.1995.63-277
DO - 10.1901/jeab.1995.63-277
M3 - Article
C2 - 7751833
AN - SCOPUS:0029299279
VL - 63
SP - 277
EP - 294
JO - Journal of the Experimental Analysis of Behavior
JF - Journal of the Experimental Analysis of Behavior
SN - 0022-5002
IS - 3
ER -