Abstract
Objectives: (1) To determine the proportion of patients with critical limb ischaemia refractory to invasive treatment that can be successfully treated by dorsal column stimulation (DCS), and (2) to identify potential responders to DCS by a simple test that is sufficiently predictive to limit the need for a prolonged trial stimulation period. Patients and methods: Twenty patients with chronic limb-threatening ischaemia were assessed by a battery of macro and microcirculatory tests and a DCS trial of 1 week. Favourable response during the trial determined selection for long term stimulation. Results: During a mean observation period of 14 months, limb salvage rate (LSR) was 63% overall and 83% among patients selected after a favourable trial. Of the tests performed preoperatively, digital subtraction angiography, Doppler assessment, oscillometry, capillaroscopy, foot temperature, and transcutaneous partial pressure of oxygen (tcpO2) in the supine or sitting position did not adequately predict DCS response. The supine-sitting tcpO2 gradient (ΔtcpO2) was a good predictor of DCS outcome, with an 88% LSR when ΔtcpO2 > 15 Torr, dropping to 12% when ΔtcpO2 > 15 Torr. Conclusions: DCS is a rewarding therapeutic option in selected patients with critical limb ischaemia. ΔtcpO2 appears to reliably predict response to DCS and may obviate trial stimulation in most cases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 464-471 |
| Number of pages | 8 |
| Journal | European Journal of Vascular and Endovascular Surgery |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Dorsal column stimulation
- Identification of potential responders
- Unreconstructible limb ischaemia
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
- Surgery
Cite this
Discriminative microcirculatory screening of patients with refractory limb ischaemia for dorsal column stimulation. / Gersbach, P.; Hasdemir, M. G.; Stevens, Robert David; Nachbur, B.; Mahler, F.
In: European Journal of Vascular and Endovascular Surgery, Vol. 13, No. 5, 1997, p. 464-471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discriminative microcirculatory screening of patients with refractory limb ischaemia for dorsal column stimulation
AU - Gersbach, P.
AU - Hasdemir, M. G.
AU - Stevens, Robert David
AU - Nachbur, B.
AU - Mahler, F.
PY - 1997
Y1 - 1997
N2 - Objectives: (1) To determine the proportion of patients with critical limb ischaemia refractory to invasive treatment that can be successfully treated by dorsal column stimulation (DCS), and (2) to identify potential responders to DCS by a simple test that is sufficiently predictive to limit the need for a prolonged trial stimulation period. Patients and methods: Twenty patients with chronic limb-threatening ischaemia were assessed by a battery of macro and microcirculatory tests and a DCS trial of 1 week. Favourable response during the trial determined selection for long term stimulation. Results: During a mean observation period of 14 months, limb salvage rate (LSR) was 63% overall and 83% among patients selected after a favourable trial. Of the tests performed preoperatively, digital subtraction angiography, Doppler assessment, oscillometry, capillaroscopy, foot temperature, and transcutaneous partial pressure of oxygen (tcpO2) in the supine or sitting position did not adequately predict DCS response. The supine-sitting tcpO2 gradient (ΔtcpO2) was a good predictor of DCS outcome, with an 88% LSR when ΔtcpO2 > 15 Torr, dropping to 12% when ΔtcpO2 > 15 Torr. Conclusions: DCS is a rewarding therapeutic option in selected patients with critical limb ischaemia. ΔtcpO2 appears to reliably predict response to DCS and may obviate trial stimulation in most cases.
AB - Objectives: (1) To determine the proportion of patients with critical limb ischaemia refractory to invasive treatment that can be successfully treated by dorsal column stimulation (DCS), and (2) to identify potential responders to DCS by a simple test that is sufficiently predictive to limit the need for a prolonged trial stimulation period. Patients and methods: Twenty patients with chronic limb-threatening ischaemia were assessed by a battery of macro and microcirculatory tests and a DCS trial of 1 week. Favourable response during the trial determined selection for long term stimulation. Results: During a mean observation period of 14 months, limb salvage rate (LSR) was 63% overall and 83% among patients selected after a favourable trial. Of the tests performed preoperatively, digital subtraction angiography, Doppler assessment, oscillometry, capillaroscopy, foot temperature, and transcutaneous partial pressure of oxygen (tcpO2) in the supine or sitting position did not adequately predict DCS response. The supine-sitting tcpO2 gradient (ΔtcpO2) was a good predictor of DCS outcome, with an 88% LSR when ΔtcpO2 > 15 Torr, dropping to 12% when ΔtcpO2 > 15 Torr. Conclusions: DCS is a rewarding therapeutic option in selected patients with critical limb ischaemia. ΔtcpO2 appears to reliably predict response to DCS and may obviate trial stimulation in most cases.
KW - Dorsal column stimulation
KW - Identification of potential responders
KW - Unreconstructible limb ischaemia
UR - http://www.scopus.com/inward/record.url?scp=0030979538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030979538&partnerID=8YFLogxK
U2 - 10.1016/S1078-5884(97)80174-8
DO - 10.1016/S1078-5884(97)80174-8
M3 - Article
C2 - 9166269
AN - SCOPUS:0030979538
VL - 13
SP - 464
EP - 471
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
IS - 5
ER -