Discriminative microcirculatory screening of patients with refractory limb ischaemia for dorsal column stimulation

P. Gersbach, M. G. Hasdemir, Robert David Stevens, B. Nachbur, F. Mahler

Research output: Contribution to journalArticle

Abstract

Objectives: (1) To determine the proportion of patients with critical limb ischaemia refractory to invasive treatment that can be successfully treated by dorsal column stimulation (DCS), and (2) to identify potential responders to DCS by a simple test that is sufficiently predictive to limit the need for a prolonged trial stimulation period. Patients and methods: Twenty patients with chronic limb-threatening ischaemia were assessed by a battery of macro and microcirculatory tests and a DCS trial of 1 week. Favourable response during the trial determined selection for long term stimulation. Results: During a mean observation period of 14 months, limb salvage rate (LSR) was 63% overall and 83% among patients selected after a favourable trial. Of the tests performed preoperatively, digital subtraction angiography, Doppler assessment, oscillometry, capillaroscopy, foot temperature, and transcutaneous partial pressure of oxygen (tcpO2) in the supine or sitting position did not adequately predict DCS response. The supine-sitting tcpO2 gradient (ΔtcpO2) was a good predictor of DCS outcome, with an 88% LSR when ΔtcpO2 > 15 Torr, dropping to 12% when ΔtcpO2 > 15 Torr. Conclusions: DCS is a rewarding therapeutic option in selected patients with critical limb ischaemia. ΔtcpO2 appears to reliably predict response to DCS and may obviate trial stimulation in most cases.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume13
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Ischemia
Extremities
Limb Salvage
Oscillometry
Microscopic Angioscopy
Digital Subtraction Angiography
Partial Pressure
Supine Position
Posture
Foot
Observation
Oxygen
Temperature
Therapeutics

Keywords

  • Dorsal column stimulation
  • Identification of potential responders
  • Unreconstructible limb ischaemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Discriminative microcirculatory screening of patients with refractory limb ischaemia for dorsal column stimulation. / Gersbach, P.; Hasdemir, M. G.; Stevens, Robert David; Nachbur, B.; Mahler, F.

In: European Journal of Vascular and Endovascular Surgery, Vol. 13, No. 5, 1997, p. 464-471.

Research output: Contribution to journalArticle

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