Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia

Efrem S. Lim, Song Cao, Lori R. Holtz, Martin Antonio, O. Colin Stine, David Wang

Research output: Contribution to journalArticle

Abstract

We describe the identification of a novel picornavirus recovered from the fecal specimen of a child in The Gambia, provisionally named rosavirus 2. Comparison of the rosavirus 2 complete genome demonstrated 71.9% nucleotide identity to its closest relative rosavirus M-7, an unclassified picornavirus identified from rodent fecal material. A unique RNA structure was predicted in the 3' UTR of rosavirus 2 that was conserved with rosavirus M-7 and cadiciviruses. We detected rosavirus 2 in four pediatric fecal specimens (0.55% prevalence) in a Gambian diarrheal case-control cohort, but we did not detect it in a panel of 634 pediatric diarrheal stool specimens from the USA. There was no statistical evidence that rosavirus 2 was associated with diarrheal cases. This study broadens our understanding of unknown viruses present in children in developing country settings.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalVirology
Volume454-455
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

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Gambia
Picornaviridae
Rodentia
Pediatrics
3' Untranslated Regions
Developing Countries
Nucleotides
Genome
RNA
Viruses
5,6-dihydroxy-2-dimethylaminotetralin

Keywords

  • Developing country
  • Emerging viruses
  • Picornavirus
  • Virus discovery

ASJC Scopus subject areas

  • Virology

Cite this

Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. / Lim, Efrem S.; Cao, Song; Holtz, Lori R.; Antonio, Martin; Stine, O. Colin; Wang, David.

In: Virology, Vol. 454-455, No. 1, 2014, p. 25-33.

Research output: Contribution to journalArticle

Lim, Efrem S. ; Cao, Song ; Holtz, Lori R. ; Antonio, Martin ; Stine, O. Colin ; Wang, David. / Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. In: Virology. 2014 ; Vol. 454-455, No. 1. pp. 25-33.
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