Discovering misattributed paternity in living kidney donation: Prevalence, preference, and practice

Ann Young, Sang Joseph Kim, Eric M. Gibney, Chirag Parikh, Meaghan S. Cuerden, Lucy D. Horvat, Patricia Hizo-Abes, Amit X. Garg

Research output: Contribution to journalReview article

Abstract

When evaluating a living kidney donor and recipient with a father-child relationship, it may be discovered that the two are not biologically related. We analyzed data from the United Network for Organ Sharing and the Canadian Organ Replacement Registry to determine how frequently this occurs. We surveyed 102 potential donors, recipients, and transplant professionals for their opinion on whether such information should be disclosed to the donor-recipient pair. We communicated with transplant professionals from 13 Canadian centers on current practices for handling this information. In the United States and Canada, the prevalence of father-child living kidney donor-recipient pairs with less than a one-haplotype human leukocyte antigen match (i.e., misattributed paternity) is between 1% and 3%, or approximately 0.25% to 0.5% of all living kidney donations. Opinions about revealing this information were variable: 23% strongly favored disclosure; whereas, 24% were strongly opposed to it. Current practices are variable; some centers disclose this information, whereas others do not. Discovering misattributed paternity in living donation is uncommon but can occur. Opinions on how to deal with this sensitive information are variable. Discussion among transplant professionals will facilitate best practices and policies. Strategies adopted by some centers can be considered.

Original languageEnglish (US)
Pages (from-to)1429-1435
Number of pages7
JournalTransplantation
Volume87
Issue number10
DOIs
StatePublished - May 27 2009

Fingerprint

Paternity
Living Donors
Kidney
Father-Child Relations
Tissue Donors
Transplants
Information Centers
Disclosure
HLA Antigens
Practice Guidelines
Fathers
Haplotypes
Canada
Registries

Keywords

  • Histocompatibility
  • Kidney transplantation
  • Living donors
  • Paternity

ASJC Scopus subject areas

  • Transplantation

Cite this

Young, A., Kim, S. J., Gibney, E. M., Parikh, C., Cuerden, M. S., Horvat, L. D., ... Garg, A. X. (2009). Discovering misattributed paternity in living kidney donation: Prevalence, preference, and practice. Transplantation, 87(10), 1429-1435. https://doi.org/10.1097/TP.0b013e3181a4eae5

Discovering misattributed paternity in living kidney donation : Prevalence, preference, and practice. / Young, Ann; Kim, Sang Joseph; Gibney, Eric M.; Parikh, Chirag; Cuerden, Meaghan S.; Horvat, Lucy D.; Hizo-Abes, Patricia; Garg, Amit X.

In: Transplantation, Vol. 87, No. 10, 27.05.2009, p. 1429-1435.

Research output: Contribution to journalReview article

Young, A, Kim, SJ, Gibney, EM, Parikh, C, Cuerden, MS, Horvat, LD, Hizo-Abes, P & Garg, AX 2009, 'Discovering misattributed paternity in living kidney donation: Prevalence, preference, and practice', Transplantation, vol. 87, no. 10, pp. 1429-1435. https://doi.org/10.1097/TP.0b013e3181a4eae5
Young, Ann ; Kim, Sang Joseph ; Gibney, Eric M. ; Parikh, Chirag ; Cuerden, Meaghan S. ; Horvat, Lucy D. ; Hizo-Abes, Patricia ; Garg, Amit X. / Discovering misattributed paternity in living kidney donation : Prevalence, preference, and practice. In: Transplantation. 2009 ; Vol. 87, No. 10. pp. 1429-1435.
@article{8e7a3c5748ed4d518b3b9c63b7ce34b9,
title = "Discovering misattributed paternity in living kidney donation: Prevalence, preference, and practice",
abstract = "When evaluating a living kidney donor and recipient with a father-child relationship, it may be discovered that the two are not biologically related. We analyzed data from the United Network for Organ Sharing and the Canadian Organ Replacement Registry to determine how frequently this occurs. We surveyed 102 potential donors, recipients, and transplant professionals for their opinion on whether such information should be disclosed to the donor-recipient pair. We communicated with transplant professionals from 13 Canadian centers on current practices for handling this information. In the United States and Canada, the prevalence of father-child living kidney donor-recipient pairs with less than a one-haplotype human leukocyte antigen match (i.e., misattributed paternity) is between 1{\%} and 3{\%}, or approximately 0.25{\%} to 0.5{\%} of all living kidney donations. Opinions about revealing this information were variable: 23{\%} strongly favored disclosure; whereas, 24{\%} were strongly opposed to it. Current practices are variable; some centers disclose this information, whereas others do not. Discovering misattributed paternity in living donation is uncommon but can occur. Opinions on how to deal with this sensitive information are variable. Discussion among transplant professionals will facilitate best practices and policies. Strategies adopted by some centers can be considered.",
keywords = "Histocompatibility, Kidney transplantation, Living donors, Paternity",
author = "Ann Young and Kim, {Sang Joseph} and Gibney, {Eric M.} and Chirag Parikh and Cuerden, {Meaghan S.} and Horvat, {Lucy D.} and Patricia Hizo-Abes and Garg, {Amit X.}",
year = "2009",
month = "5",
day = "27",
doi = "10.1097/TP.0b013e3181a4eae5",
language = "English (US)",
volume = "87",
pages = "1429--1435",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Discovering misattributed paternity in living kidney donation

T2 - Prevalence, preference, and practice

AU - Young, Ann

AU - Kim, Sang Joseph

AU - Gibney, Eric M.

AU - Parikh, Chirag

AU - Cuerden, Meaghan S.

AU - Horvat, Lucy D.

AU - Hizo-Abes, Patricia

AU - Garg, Amit X.

PY - 2009/5/27

Y1 - 2009/5/27

N2 - When evaluating a living kidney donor and recipient with a father-child relationship, it may be discovered that the two are not biologically related. We analyzed data from the United Network for Organ Sharing and the Canadian Organ Replacement Registry to determine how frequently this occurs. We surveyed 102 potential donors, recipients, and transplant professionals for their opinion on whether such information should be disclosed to the donor-recipient pair. We communicated with transplant professionals from 13 Canadian centers on current practices for handling this information. In the United States and Canada, the prevalence of father-child living kidney donor-recipient pairs with less than a one-haplotype human leukocyte antigen match (i.e., misattributed paternity) is between 1% and 3%, or approximately 0.25% to 0.5% of all living kidney donations. Opinions about revealing this information were variable: 23% strongly favored disclosure; whereas, 24% were strongly opposed to it. Current practices are variable; some centers disclose this information, whereas others do not. Discovering misattributed paternity in living donation is uncommon but can occur. Opinions on how to deal with this sensitive information are variable. Discussion among transplant professionals will facilitate best practices and policies. Strategies adopted by some centers can be considered.

AB - When evaluating a living kidney donor and recipient with a father-child relationship, it may be discovered that the two are not biologically related. We analyzed data from the United Network for Organ Sharing and the Canadian Organ Replacement Registry to determine how frequently this occurs. We surveyed 102 potential donors, recipients, and transplant professionals for their opinion on whether such information should be disclosed to the donor-recipient pair. We communicated with transplant professionals from 13 Canadian centers on current practices for handling this information. In the United States and Canada, the prevalence of father-child living kidney donor-recipient pairs with less than a one-haplotype human leukocyte antigen match (i.e., misattributed paternity) is between 1% and 3%, or approximately 0.25% to 0.5% of all living kidney donations. Opinions about revealing this information were variable: 23% strongly favored disclosure; whereas, 24% were strongly opposed to it. Current practices are variable; some centers disclose this information, whereas others do not. Discovering misattributed paternity in living donation is uncommon but can occur. Opinions on how to deal with this sensitive information are variable. Discussion among transplant professionals will facilitate best practices and policies. Strategies adopted by some centers can be considered.

KW - Histocompatibility

KW - Kidney transplantation

KW - Living donors

KW - Paternity

UR - http://www.scopus.com/inward/record.url?scp=67649628405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649628405&partnerID=8YFLogxK

U2 - 10.1097/TP.0b013e3181a4eae5

DO - 10.1097/TP.0b013e3181a4eae5

M3 - Review article

C2 - 19461476

AN - SCOPUS:67649628405

VL - 87

SP - 1429

EP - 1435

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 10

ER -