Abstract
Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overviews of these changes, as well identify key genes and pathways involved in this process. This review outlines the current roles of these techniques in cancer research, and how they may contribute to finding not only mechanisms of this disease, but potential targets for therapy.
Original language | English (US) |
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Pages (from-to) | 548-563 |
Number of pages | 16 |
Journal | Ageing Research Reviews |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Nov 2005 |
Externally published | Yes |
Keywords
- Cancer
- Gene expression profiling
- Microarray
- SAGE
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Aging
- Molecular Biology
- Neurology