Discovering causes and cures for cancer from gene expression analysis

Research output: Contribution to journalShort surveypeer-review

Abstract

Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overviews of these changes, as well identify key genes and pathways involved in this process. This review outlines the current roles of these techniques in cancer research, and how they may contribute to finding not only mechanisms of this disease, but potential targets for therapy.

Original languageEnglish (US)
Pages (from-to)548-563
Number of pages16
JournalAgeing Research Reviews
Volume4
Issue number4
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • Cancer
  • Gene expression profiling
  • Microarray
  • SAGE

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

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