Discovering and deciphering relationships across disparate data modalities

Joshua T. Vogelstein, Eric W. Bridgeford, Qing Wang, Carey E. Priebe, Mauro Maggioni, Cencheng Shen

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding the relationships between different properties of data, such as whether a genome or connectome has information about disease status, is increasingly important. While existing approaches can test whether two properties are related, they may require unfeasibly large sample sizes and often are not interpretable. Our approach, 'Multiscale Graph Correlation' (MGC), is a dependence test that juxtaposes disparate data science techniques, including k-nearest neighbors, kernel methods, and multiscale analysis. Other methods may require double or triple the number of samples to achieve the same statistical power as MGC in a benchmark suite including high-dimensional and nonlinear relationships, with dimensionality ranging from 1 to 1000. Moreover, MGC uniquely characterizes the latent geometry underlying the relationship, while maintaining computational efficiency. In real data, including brain imaging and cancer genetics, MGC detects the presence of a dependency and provides guidance for the next experiments to conduct.

Original languageEnglish (US)
JournaleLife
Volume8
DOIs
StatePublished - Jan 15 2019

Keywords

  • computational biology
  • data science
  • human
  • machine learning
  • neuroscience
  • statistics
  • systems biology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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