DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity

Amy Gancarz; Yan Jouroukhin; Atsushi Saito; Alexey Shevelkin; Lauren E. Mueller; Atsushi Kamiya; David M. Dietz; Mikhail V. Pletnikov

doi:10.1016/j.neures.2015.09.001

DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity

Amy Gancarz, Yan Jouroukhin, Atsushi Saito, Alexey Shevelkin, Lauren E. Mueller, Atsushi Kamiya, David M. Dietz, Mikhail V. Pletnikov

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Substance abuse and other psychiatric diseases may share molecular pathology. In order to test this hypothesis, we examined the role of Disrupted In Schizophrenia 1 (DISC1), a psychiatric risk factor, in cocaine self-administration (SA). Cocaine SA significantly increased expression of DISC1 in the nucleus accumbens (NAc); while knockdown of DISC1 in NAc significantly increased cocaine SA and decreased phosphorylation of GSK-3β at Ser9 compared to scrambled shRNA. Our study provides the first mechanistic evidence of a critical role of DISC1 in drug-induced behavioral neuroadaptations and sheds more light at the shared molecular pathology of drug abuse and other major psychiatric disorders.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	Neuroscience Research
Volume	105
DOIs	https://doi.org/10.1016/j.neures.2015.09.001
State	Published - Apr 1 2016

Keywords

Co-morbidity
Cocaine
DISC1
Drug abuse
Psychiatric disorders

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neures.2015.09.001

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title = "DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity",

abstract = "Substance abuse and other psychiatric diseases may share molecular pathology. In order to test this hypothesis, we examined the role of Disrupted In Schizophrenia 1 (DISC1), a psychiatric risk factor, in cocaine self-administration (SA). Cocaine SA significantly increased expression of DISC1 in the nucleus accumbens (NAc); while knockdown of DISC1 in NAc significantly increased cocaine SA and decreased phosphorylation of GSK-3β at Ser9 compared to scrambled shRNA. Our study provides the first mechanistic evidence of a critical role of DISC1 in drug-induced behavioral neuroadaptations and sheds more light at the shared molecular pathology of drug abuse and other major psychiatric disorders.",

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T2 - Towards molecular mechanisms of co-morbidity

AU - Gancarz, Amy

AU - Jouroukhin, Yan

AU - Saito, Atsushi

AU - Shevelkin, Alexey

AU - Mueller, Lauren E.

AU - Kamiya, Atsushi

AU - Dietz, David M.

AU - Pletnikov, Mikhail V.

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AB - Substance abuse and other psychiatric diseases may share molecular pathology. In order to test this hypothesis, we examined the role of Disrupted In Schizophrenia 1 (DISC1), a psychiatric risk factor, in cocaine self-administration (SA). Cocaine SA significantly increased expression of DISC1 in the nucleus accumbens (NAc); while knockdown of DISC1 in NAc significantly increased cocaine SA and decreased phosphorylation of GSK-3β at Ser9 compared to scrambled shRNA. Our study provides the first mechanistic evidence of a critical role of DISC1 in drug-induced behavioral neuroadaptations and sheds more light at the shared molecular pathology of drug abuse and other major psychiatric disorders.

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KW - DISC1

KW - Drug abuse

KW - Psychiatric disorders

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DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity

Abstract

Keywords

ASJC Scopus subject areas

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