DISC1 mouse models

Yavuz Ayhan, Hanna Jaaro-Peled, Akira Sawa, Mikhail V. Pletnikov

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Disrupted-in-Schizophrenia 1 (DISC1) is a strong candidate gene for schizophrenia and major mental disorders. After its discovery in the Scottish chromosomal translocation, DISC1 has gained considerable attention in neuropsychiatric research. Recent studies have implicated DISC1 in fundamental processes of neurodevelopment and adulthood neuroplasticity. To get more insights into the functions of DISC1 in vivo, several mouse DISC1 models have been generated based on different approaches, including constitutive and inducible over-expression of different fragments of DISC1, targeted mutagenesis, and viral vector knockdown. Each model has provided important information regarding DISC1 functions and helped in elucidating the molecular pathways underlying behavioral disorders. The existing models also serve as valuable tools to address complex issues of the pathogenesis of schizophrenia, including gene-gene and gene-environment interactions. Here, we critically overview current DISC1 mouse models. Future directions in DISC1 mouse models and alternative approaches are discussed.

Original languageEnglish (US)
Title of host publicationAnimal Models of Schizophrenia and Related Disorders
EditorsPatrick O'Donnell
Pages211-229
Number of pages19
DOIs
StatePublished - Jul 1 2011

Publication series

NameNeuromethods
Volume59
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • DISC1
  • depression
  • mouse models
  • neurodevelopment
  • schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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