Abstract
Molecular mechanisms underlying the pathogenesis of schizophrenia remains elusive. The difficulty in accessing the mechanisms stems from, at least in part, multiple etiologies for schizophrenia. We have studied DISC1, as it was identified as a candidate gene for a schizophrenia-associated mental condition with the single etiology. Thus far, we have obtained evidence that DISC1 may have implications in neurodevelopment. This concept fits with many historical observations found for schizophrenia in association with neurodevelopmental abnormalities. DISC1 may become one of the key molecules in studying the pathogenesis of schizophrenia.
Original language | English (US) |
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Pages (from-to) | 87-91 |
Number of pages | 5 |
Journal | Japanese Journal of Neuropsychopharmacology |
Volume | 24 |
Issue number | 2 |
State | Published - Apr 1 2004 |
Externally published | Yes |
Keywords
- DISC1
- NUDEL
- Neurodevelopmental abnormality
- Schizophrenia
ASJC Scopus subject areas
- Clinical Psychology
- Pharmacology
- Psychiatry and Mental health
- Pharmacology (medical)