TY - JOUR
T1 - Disability in moderate chronic obstructive pulmonary disease
T2 - Prevalence, burden and assessment-results from a real-life study
AU - Braido, Fulvio
AU - Baiardini, Ilaria
AU - Scichilone, Nicola
AU - Sorino, Claudio
AU - Di Marco, Fabiano
AU - Corsico, Angelo
AU - Santus, Pierachille
AU - Girbino, Giuseppe
AU - Di Maria, Giuseppe
AU - Mereu, Carlo
AU - Sabato, Eugenio
AU - Foschino Barbaro, Maria Pia
AU - Cuttitta, Giuseppina
AU - Zolezzi, Alberto
AU - Bucca, Caterina
AU - Balestracci, Sara
AU - Canonica, Giorgio Walter
N1 - Publisher Copyright:
© 2015 S. Karger AG, Basel.
PY - 2015/3/6
Y1 - 2015/3/6
N2 - Background: The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. Objectives: The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. Methods: Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collection method. Results: Out of 694 patients, 17.4% were classified as disabled and 47.6% reported the loss of at least one relevant function of daily living. Disabled patients did not differ from nondisabled patients in terms of working status (p = 0.06), smoking habits (p = 0.134) and ongoing treatment (p = 0.823); however, the former showed a significantly higher disease burden as measured by illness perception, health status and well-being. The stepwise regression analysis showed that the modified Medical Research Council (mMRC) score was the most relevant factor related to COPD disability (F = 38.248; p = 0.001). Patient stratification was possible according to the forced expiratory volume in 1 s (FEV1) value and an mMRC score ≥2, which identified disabled patients, whereas the mMRC values were differently associated with the risk of disability. Conclusion: A significant proportion of individuals with moderate COPD reported a limitation of daily life functions, with dyspnea being the most relevant factor inducing disability. Adding the evaluation of patient-reported outcomes to lung function assessment could facilitate the identification of disabled patients.
AB - Background: The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. Objectives: The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. Methods: Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collection method. Results: Out of 694 patients, 17.4% were classified as disabled and 47.6% reported the loss of at least one relevant function of daily living. Disabled patients did not differ from nondisabled patients in terms of working status (p = 0.06), smoking habits (p = 0.134) and ongoing treatment (p = 0.823); however, the former showed a significantly higher disease burden as measured by illness perception, health status and well-being. The stepwise regression analysis showed that the modified Medical Research Council (mMRC) score was the most relevant factor related to COPD disability (F = 38.248; p = 0.001). Patient stratification was possible according to the forced expiratory volume in 1 s (FEV1) value and an mMRC score ≥2, which identified disabled patients, whereas the mMRC values were differently associated with the risk of disability. Conclusion: A significant proportion of individuals with moderate COPD reported a limitation of daily life functions, with dyspnea being the most relevant factor inducing disability. Adding the evaluation of patient-reported outcomes to lung function assessment could facilitate the identification of disabled patients.
KW - Chronic obstructive pulmonary disease
KW - Disability
KW - Patient-reported outcomes
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U2 - 10.1159/000368365
DO - 10.1159/000368365
M3 - Article
C2 - 25612914
AN - SCOPUS:84924249944
SN - 0025-7931
VL - 89
SP - 100
EP - 106
JO - Respiration
JF - Respiration
IS - 2
ER -