Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study

Fulvio Braido, Ilaria Baiardini, Nicola Scichilone, Claudio Sorino, Fabiano Di Marco, Angelo Corsico, Pierachille Santus, Giuseppe Girbino, Giuseppe Di Maria, Carlo Mereu, Eugenio Sabato, Maria Pia Foschino Barbaro, Giuseppina Cuttitta, Alberto Zolezzi, Caterina Bucca, Sara Balestracci, Giorgio Walter Canonica

Research output: Contribution to journalArticle

Abstract

Background: The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. Objectives: The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. Methods: Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collection method. Results: Out of 694 patients, 17.4% were classified as disabled and 47.6% reported the loss of at least one relevant function of daily living. Disabled patients did not differ from nondisabled patients in terms of working status (p = 0.06), smoking habits (p = 0.134) and ongoing treatment (p = 0.823); however, the former showed a significantly higher disease burden as measured by illness perception, health status and well-being. The stepwise regression analysis showed that the modified Medical Research Council (mMRC) score was the most relevant factor related to COPD disability (F = 38.248; p = 0.001). Patient stratification was possible according to the forced expiratory volume in 1 s (FEV1) value and an mMRC score ≥2, which identified disabled patients, whereas the mMRC values were differently associated with the risk of disability. Conclusion: A significant proportion of individuals with moderate COPD reported a limitation of daily life functions, with dyspnea being the most relevant factor inducing disability. Adding the evaluation of patient-reported outcomes to lung function assessment could facilitate the identification of disabled patients.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalRespiration
Volume89
Issue number2
DOIs
StatePublished - Mar 6 2015
Externally publishedYes

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Chronic Obstructive Pulmonary Disease
Biomedical Research
Health Status
Forced Expiratory Volume
Dyspnea
Habits
Outpatients
Cross-Sectional Studies
Smoking
Regression Analysis
Lung
Research

Keywords

  • Chronic obstructive pulmonary disease
  • Disability
  • Patient-reported outcomes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Braido, F., Baiardini, I., Scichilone, N., Sorino, C., Di Marco, F., Corsico, A., ... Canonica, G. W. (2015). Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study. Respiration, 89(2), 100-106. https://doi.org/10.1159/000368365

Disability in moderate chronic obstructive pulmonary disease : Prevalence, burden and assessment-results from a real-life study. / Braido, Fulvio; Baiardini, Ilaria; Scichilone, Nicola; Sorino, Claudio; Di Marco, Fabiano; Corsico, Angelo; Santus, Pierachille; Girbino, Giuseppe; Di Maria, Giuseppe; Mereu, Carlo; Sabato, Eugenio; Foschino Barbaro, Maria Pia; Cuttitta, Giuseppina; Zolezzi, Alberto; Bucca, Caterina; Balestracci, Sara; Canonica, Giorgio Walter.

In: Respiration, Vol. 89, No. 2, 06.03.2015, p. 100-106.

Research output: Contribution to journalArticle

Braido, F, Baiardini, I, Scichilone, N, Sorino, C, Di Marco, F, Corsico, A, Santus, P, Girbino, G, Di Maria, G, Mereu, C, Sabato, E, Foschino Barbaro, MP, Cuttitta, G, Zolezzi, A, Bucca, C, Balestracci, S & Canonica, GW 2015, 'Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study', Respiration, vol. 89, no. 2, pp. 100-106. https://doi.org/10.1159/000368365
Braido, Fulvio ; Baiardini, Ilaria ; Scichilone, Nicola ; Sorino, Claudio ; Di Marco, Fabiano ; Corsico, Angelo ; Santus, Pierachille ; Girbino, Giuseppe ; Di Maria, Giuseppe ; Mereu, Carlo ; Sabato, Eugenio ; Foschino Barbaro, Maria Pia ; Cuttitta, Giuseppina ; Zolezzi, Alberto ; Bucca, Caterina ; Balestracci, Sara ; Canonica, Giorgio Walter. / Disability in moderate chronic obstructive pulmonary disease : Prevalence, burden and assessment-results from a real-life study. In: Respiration. 2015 ; Vol. 89, No. 2. pp. 100-106.
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AU - Baiardini, Ilaria

AU - Scichilone, Nicola

AU - Sorino, Claudio

AU - Di Marco, Fabiano

AU - Corsico, Angelo

AU - Santus, Pierachille

AU - Girbino, Giuseppe

AU - Di Maria, Giuseppe

AU - Mereu, Carlo

AU - Sabato, Eugenio

AU - Foschino Barbaro, Maria Pia

AU - Cuttitta, Giuseppina

AU - Zolezzi, Alberto

AU - Bucca, Caterina

AU - Balestracci, Sara

AU - Canonica, Giorgio Walter

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N2 - Background: The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. Objectives: The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. Methods: Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collection method. Results: Out of 694 patients, 17.4% were classified as disabled and 47.6% reported the loss of at least one relevant function of daily living. Disabled patients did not differ from nondisabled patients in terms of working status (p = 0.06), smoking habits (p = 0.134) and ongoing treatment (p = 0.823); however, the former showed a significantly higher disease burden as measured by illness perception, health status and well-being. The stepwise regression analysis showed that the modified Medical Research Council (mMRC) score was the most relevant factor related to COPD disability (F = 38.248; p = 0.001). Patient stratification was possible according to the forced expiratory volume in 1 s (FEV1) value and an mMRC score ≥2, which identified disabled patients, whereas the mMRC values were differently associated with the risk of disability. Conclusion: A significant proportion of individuals with moderate COPD reported a limitation of daily life functions, with dyspnea being the most relevant factor inducing disability. Adding the evaluation of patient-reported outcomes to lung function assessment could facilitate the identification of disabled patients.

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