Directional guidance of nerve growth cones

Zhexing Wen, James Q. Zheng

Research output: Contribution to journalArticle

Abstract

The intricate connections of the nervous system are established, in part, by elongating axonal fibers that are directed by complex guidance systems to home in on their specific targets. The growth cone, the major motile apparatus at the tip of axons, explores its surroundings and steers the axon along a defined path to its appropriate target. Significant progress has been made in identifying the guidance molecules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct growth cone behaviors, and the cytoskeletal components that give rise to the directional motility of the growth cone. Recent studies have also shed light on the sophisticated mechanisms and new players utilized by the growth cone during pathfinding. It is clear that axon pathfinding requires a growth cone to sample and integrate various signals both in space and in time, and subsequently to coordinate the dynamics of its membrane, cytoskeleton and adhesion to generate specific responses.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume16
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Growth Cones
Axons
Cytoskeleton
Nervous System
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Directional guidance of nerve growth cones. / Wen, Zhexing; Zheng, James Q.

In: Current Opinion in Neurobiology, Vol. 16, No. 1, 02.2006, p. 52-58.

Research output: Contribution to journalArticle

Wen, Zhexing ; Zheng, James Q. / Directional guidance of nerve growth cones. In: Current Opinion in Neurobiology. 2006 ; Vol. 16, No. 1. pp. 52-58.
@article{df62b6b418ff407c9d82c873573efbda,
title = "Directional guidance of nerve growth cones",
abstract = "The intricate connections of the nervous system are established, in part, by elongating axonal fibers that are directed by complex guidance systems to home in on their specific targets. The growth cone, the major motile apparatus at the tip of axons, explores its surroundings and steers the axon along a defined path to its appropriate target. Significant progress has been made in identifying the guidance molecules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct growth cone behaviors, and the cytoskeletal components that give rise to the directional motility of the growth cone. Recent studies have also shed light on the sophisticated mechanisms and new players utilized by the growth cone during pathfinding. It is clear that axon pathfinding requires a growth cone to sample and integrate various signals both in space and in time, and subsequently to coordinate the dynamics of its membrane, cytoskeleton and adhesion to generate specific responses.",
author = "Zhexing Wen and Zheng, {James Q.}",
year = "2006",
month = "2",
doi = "10.1016/j.conb.2005.12.005",
language = "English (US)",
volume = "16",
pages = "52--58",
journal = "Current Opinion in Neurobiology",
issn = "0959-4388",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Directional guidance of nerve growth cones

AU - Wen, Zhexing

AU - Zheng, James Q.

PY - 2006/2

Y1 - 2006/2

N2 - The intricate connections of the nervous system are established, in part, by elongating axonal fibers that are directed by complex guidance systems to home in on their specific targets. The growth cone, the major motile apparatus at the tip of axons, explores its surroundings and steers the axon along a defined path to its appropriate target. Significant progress has been made in identifying the guidance molecules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct growth cone behaviors, and the cytoskeletal components that give rise to the directional motility of the growth cone. Recent studies have also shed light on the sophisticated mechanisms and new players utilized by the growth cone during pathfinding. It is clear that axon pathfinding requires a growth cone to sample and integrate various signals both in space and in time, and subsequently to coordinate the dynamics of its membrane, cytoskeleton and adhesion to generate specific responses.

AB - The intricate connections of the nervous system are established, in part, by elongating axonal fibers that are directed by complex guidance systems to home in on their specific targets. The growth cone, the major motile apparatus at the tip of axons, explores its surroundings and steers the axon along a defined path to its appropriate target. Significant progress has been made in identifying the guidance molecules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct growth cone behaviors, and the cytoskeletal components that give rise to the directional motility of the growth cone. Recent studies have also shed light on the sophisticated mechanisms and new players utilized by the growth cone during pathfinding. It is clear that axon pathfinding requires a growth cone to sample and integrate various signals both in space and in time, and subsequently to coordinate the dynamics of its membrane, cytoskeleton and adhesion to generate specific responses.

UR - http://www.scopus.com/inward/record.url?scp=32344435872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32344435872&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2005.12.005

DO - 10.1016/j.conb.2005.12.005

M3 - Article

C2 - 16387488

AN - SCOPUS:32344435872

VL - 16

SP - 52

EP - 58

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

IS - 1

ER -