Directing human embryonic stem cells to generate vascular progenitor cells

H. Bai; Z. Z. Wang

doi:10.1038/sj.gt.3303005

Directing human embryonic stem cells to generate vascular progenitor cells

H. Bai, Z. Z. Wang

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Pluripotent human embryonic stem cells (hESCs) differentiate into most of the cell types of the adult human body, including vascular cells. Vascular cells, such as endothelial cells and vascular smooth muscle cells (SMCs) are significant contributors to tissue repair and regeneration. In addition to their potential applications for treatment of vascular diseases and stimulation of ischemic tissue growth, it is also possible that endothelial cells and SMCs derived from hESCs can be used to engineer artificial vessels to repair damaged vessels and form vessel networks in engineered tissues. Here we review the current status of directing hESCs to differentiate to vascular cells.

Original language	English (US)
Pages (from-to)	89-95
Number of pages	7
Journal	Gene Therapy
Volume	15
Issue number	2
DOIs	https://doi.org/10.1038/sj.gt.3303005
State	Published - Jan 2008
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics

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10.1038/sj.gt.3303005

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title = "Directing human embryonic stem cells to generate vascular progenitor cells",

abstract = "Pluripotent human embryonic stem cells (hESCs) differentiate into most of the cell types of the adult human body, including vascular cells. Vascular cells, such as endothelial cells and vascular smooth muscle cells (SMCs) are significant contributors to tissue repair and regeneration. In addition to their potential applications for treatment of vascular diseases and stimulation of ischemic tissue growth, it is also possible that endothelial cells and SMCs derived from hESCs can be used to engineer artificial vessels to repair damaged vessels and form vessel networks in engineered tissues. Here we review the current status of directing hESCs to differentiate to vascular cells.",

author = "H. Bai and Wang, {Z. Z.}",

note = "Funding Information: I acknowledge our colleagues in the field for their many outstanding studies. This work was supported by National Institute of Health Grants K01DK064696 and P20RR018789.",

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AU - Wang, Z. Z.

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PY - 2008/1

Y1 - 2008/1

N2 - Pluripotent human embryonic stem cells (hESCs) differentiate into most of the cell types of the adult human body, including vascular cells. Vascular cells, such as endothelial cells and vascular smooth muscle cells (SMCs) are significant contributors to tissue repair and regeneration. In addition to their potential applications for treatment of vascular diseases and stimulation of ischemic tissue growth, it is also possible that endothelial cells and SMCs derived from hESCs can be used to engineer artificial vessels to repair damaged vessels and form vessel networks in engineered tissues. Here we review the current status of directing hESCs to differentiate to vascular cells.

AB - Pluripotent human embryonic stem cells (hESCs) differentiate into most of the cell types of the adult human body, including vascular cells. Vascular cells, such as endothelial cells and vascular smooth muscle cells (SMCs) are significant contributors to tissue repair and regeneration. In addition to their potential applications for treatment of vascular diseases and stimulation of ischemic tissue growth, it is also possible that endothelial cells and SMCs derived from hESCs can be used to engineer artificial vessels to repair damaged vessels and form vessel networks in engineered tissues. Here we review the current status of directing hESCs to differentiate to vascular cells.

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Directing human embryonic stem cells to generate vascular progenitor cells

Abstract

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