Directing human embryonic stem cells to generate vascular progenitor cells

H. Bai, Zack Z. Wang

Research output: Contribution to journalArticle

Abstract

Pluripotent human embryonic stem cells (hESCs) differentiate into most of the cell types of the adult human body, including vascular cells. Vascular cells, such as endothelial cells and vascular smooth muscle cells (SMCs) are significant contributors to tissue repair and regeneration. In addition to their potential applications for treatment of vascular diseases and stimulation of ischemic tissue growth, it is also possible that endothelial cells and SMCs derived from hESCs can be used to engineer artificial vessels to repair damaged vessels and form vessel networks in engineered tissues. Here we review the current status of directing hESCs to differentiate to vascular cells.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalGene Therapy
Volume15
Issue number2
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Blood Vessels
Stem Cells
Smooth Muscle Myocytes
Endothelial Cells
Vascular Diseases
Vascular Smooth Muscle
Human Body
Regeneration
Human Embryonic Stem Cells
Growth
Therapeutics

ASJC Scopus subject areas

  • Genetics

Cite this

Directing human embryonic stem cells to generate vascular progenitor cells. / Bai, H.; Wang, Zack Z.

In: Gene Therapy, Vol. 15, No. 2, 01.2008, p. 89-95.

Research output: Contribution to journalArticle

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