Directed inflammation: The phylogeny of lymphokines

R. A. Prendergast; G. A. Lutty; A. L. Scott

doi:10.1016/0145-305X(83)90080-0

Directed inflammation: The phylogeny of lymphokines

R. A. Prendergast, G. A. Lutty, A. L. Scott

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Implants of slow-release polymer Elvax-40 containing purified sea star factor (SSF) and rabbit T cell lymphokines were sutured to the coelomic wall of the distal arms of the sea star Asterias forbesi. Scanning electron microscopic evaluation of the pellet surface demonstrated adherence and spreading of coelomocytes over SSF- or lymphokine-containing pellets examined from 6 to 48 hours after implantation. These observations indicate that purified SSF and rabbit lymphokines demonstrate cross-phylum biological mimicry, implying a phylogenetic link between vertebrate and invertebrate cell communication mechanisms in immunoprotective functions.

Original language	English (US)
Pages (from-to)	629-632
Number of pages	4
Journal	Developmental and Comparative Immunology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0145-305X(83)90080-0
State	Published - 1983

ASJC Scopus subject areas

Immunology
Developmental Biology

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10.1016/0145-305X(83)90080-0

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title = "Directed inflammation: The phylogeny of lymphokines",

abstract = "Implants of slow-release polymer Elvax-40 containing purified sea star factor (SSF) and rabbit T cell lymphokines were sutured to the coelomic wall of the distal arms of the sea star Asterias forbesi. Scanning electron microscopic evaluation of the pellet surface demonstrated adherence and spreading of coelomocytes over SSF- or lymphokine-containing pellets examined from 6 to 48 hours after implantation. These observations indicate that purified SSF and rabbit lymphokines demonstrate cross-phylum biological mimicry, implying a phylogenetic link between vertebrate and invertebrate cell communication mechanisms in immunoprotective functions.",

author = "Prendergast, {R. A.} and Lutty, {G. A.} and Scott, {A. L.}",

note = "Funding Information: This work was supported in part by United States Public Health Service grants EY-0352 1 and EY-02650 from the National Institutes of Health.",

year = "1983",

doi = "10.1016/0145-305X(83)90080-0",

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T1 - Directed inflammation

T2 - The phylogeny of lymphokines

AU - Prendergast, R. A.

AU - Lutty, G. A.

AU - Scott, A. L.

N1 - Funding Information: This work was supported in part by United States Public Health Service grants EY-0352 1 and EY-02650 from the National Institutes of Health.

PY - 1983

Y1 - 1983

N2 - Implants of slow-release polymer Elvax-40 containing purified sea star factor (SSF) and rabbit T cell lymphokines were sutured to the coelomic wall of the distal arms of the sea star Asterias forbesi. Scanning electron microscopic evaluation of the pellet surface demonstrated adherence and spreading of coelomocytes over SSF- or lymphokine-containing pellets examined from 6 to 48 hours after implantation. These observations indicate that purified SSF and rabbit lymphokines demonstrate cross-phylum biological mimicry, implying a phylogenetic link between vertebrate and invertebrate cell communication mechanisms in immunoprotective functions.

AB - Implants of slow-release polymer Elvax-40 containing purified sea star factor (SSF) and rabbit T cell lymphokines were sutured to the coelomic wall of the distal arms of the sea star Asterias forbesi. Scanning electron microscopic evaluation of the pellet surface demonstrated adherence and spreading of coelomocytes over SSF- or lymphokine-containing pellets examined from 6 to 48 hours after implantation. These observations indicate that purified SSF and rabbit lymphokines demonstrate cross-phylum biological mimicry, implying a phylogenetic link between vertebrate and invertebrate cell communication mechanisms in immunoprotective functions.

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Directed inflammation: The phylogeny of lymphokines

Abstract

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