TY - GEN
T1 - Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface
AU - Lee, Sanghoon
AU - Wang, Hao
AU - Peh, Wendy Yen Xian
AU - Thakor, Nitish V.
AU - Yen, Shih Cheng
AU - Lee, Chengkuo
N1 - Funding Information:
The authors would like to acknowledge financial support from the following research grants: NRF-CRP10-2012-01 “Peripheral Nerve Prostheses: A Paradigm Shift in Restoring Dexterous Limb Function” and NRFCRP8-2011-01 “Self-powered body sensor for disease management and prevention-orientated healthcare” from the National Research Foundation (NRF), Singapore, and Faculty Research Committee (FRC) grant “Thermoelectric Power Generator (TEG) Based Self-Powered ECG Plaster—System Integration (Part 3)” at the National University of Singapore, The DGIST Start-up Fund Program of the Ministry of Science and ICT 2018090020.
Funding Information:
This work was funded by the National Research Foundation in Singapore (NRF-CRP10-2012-01), The DGIST Start-up Fund Program of the Ministry of Science and ICT 2018090020.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/5/16
Y1 - 2019/5/16
N2 - This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.
AB - This paper reports direct stimulation of bladder pelvic nerve using a battery-free neural clip interface. We implanted a flexible neural clip interface combined with a triboelectric nanogenerator (TENG) on a bladder pelvic nerve in rats to directly modulate bladder functions for the first time. The stimulation parameters such as currents, pulse width, and charges generated by the TENG were characterized. In an in vivo experiment, different numbers of pulses were applied to stimulate the pelvic nerve while monitoring changes in bladder pressure and the occurrence of micturition. The bladder contraction with micturition was observed for all experiments, except when applying a single pulse for the stimulation. The results demonstrate that this technology may potentially be used for direct modulation of bladder function.
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U2 - 10.1109/NER.2019.8716975
DO - 10.1109/NER.2019.8716975
M3 - Conference contribution
AN - SCOPUS:85066759463
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 706
EP - 709
BT - 9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PB - IEEE Computer Society
T2 - 9th International IEEE EMBS Conference on Neural Engineering, NER 2019
Y2 - 20 March 2019 through 23 March 2019
ER -