TY - JOUR
T1 - Direct-Smear Fluorescent Antibody Cytology as a Field Diagnostic Tool for Trachoma
AU - Wilson, Martha C.
AU - Millan Velasco, Francisco
AU - Tielsch, James M.
AU - Taylor, Hugh R.
PY - 1986/5
Y1 - 1986/5
N2 - A recently developed direct-smear fluorescent antibody (DFA) cytology method of detecting chlamydial infection was evaluated in an area where trachoma is endemic. Four hundred seventy-five children aged 2 to 10 years were examined, and adequate conjunctival cytology specimens were collected from 457 (96%). Trachomatous inflammatory changes were observed in 114 (25%) of the children. The DFA cytologic technique has a high specificity (100%) but a low sensitivity (8%). It offers a number of advantages over existing laboratory methods for diagnosing trachoma in the field. It is a rapid, simple, and easily transferred test that has a high specificity. Although DFA cytology shares the low sensitivity of other laboratory methods of diagnosing trachoma, we believe its logistical advantages make it the laboratory test of choice.
AB - A recently developed direct-smear fluorescent antibody (DFA) cytology method of detecting chlamydial infection was evaluated in an area where trachoma is endemic. Four hundred seventy-five children aged 2 to 10 years were examined, and adequate conjunctival cytology specimens were collected from 457 (96%). Trachomatous inflammatory changes were observed in 114 (25%) of the children. The DFA cytologic technique has a high specificity (100%) but a low sensitivity (8%). It offers a number of advantages over existing laboratory methods for diagnosing trachoma in the field. It is a rapid, simple, and easily transferred test that has a high specificity. Although DFA cytology shares the low sensitivity of other laboratory methods of diagnosing trachoma, we believe its logistical advantages make it the laboratory test of choice.
UR - http://www.scopus.com/inward/record.url?scp=0022540292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022540292&partnerID=8YFLogxK
U2 - 10.1001/archopht.1986.01050170078026
DO - 10.1001/archopht.1986.01050170078026
M3 - Article
C2 - 3518681
AN - SCOPUS:0022540292
SN - 0003-9950
VL - 104
SP - 688
EP - 690
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 5
ER -