Direct profiling of tissue lipids by MALDI-TOFMS

Shelley N. Jackson; Amina S. Woods

doi:10.1016/j.jchromb.2008.11.033

Direct profiling of tissue lipids by MALDI-TOFMS

Shelley N. Jackson, Amina S. Woods

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Advances in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) have allowed for the direct analysis of biological molecules from tissue. Although most of the early studies of direct tissue profiling by MALDI-TOFMS have focused on proteins and peptides, analysis of lipids has increased dramatically in recent years. This review gives an overview of the factors to consider when analyzing lipids directly from tissue and some recent examples of the use of MALDI-TOFMS for the direct profiling of lipids in tissue.

Original language	English (US)
Pages (from-to)	2822-2829
Number of pages	8
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	877
Issue number	26
DOIs	https://doi.org/10.1016/j.jchromb.2008.11.033
State	Published - Sep 15 2009
Externally published	Yes

Keywords

Direct profiling
Lipids
MALDI
MS/MS
Tissue

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Cell Biology
Clinical Biochemistry

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10.1016/j.jchromb.2008.11.033

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AB - Advances in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) have allowed for the direct analysis of biological molecules from tissue. Although most of the early studies of direct tissue profiling by MALDI-TOFMS have focused on proteins and peptides, analysis of lipids has increased dramatically in recent years. This review gives an overview of the factors to consider when analyzing lipids directly from tissue and some recent examples of the use of MALDI-TOFMS for the direct profiling of lipids in tissue.

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KW - MALDI

KW - MS/MS

KW - Tissue

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Direct profiling of tissue lipids by MALDI-TOFMS

Abstract

Keywords

ASJC Scopus subject areas

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