Direct profiling of tissue lipids by MALDI-TOFMS

Shelley N. Jackson, Amina S. Woods

Research output: Contribution to journalArticle

Abstract

Advances in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) have allowed for the direct analysis of biological molecules from tissue. Although most of the early studies of direct tissue profiling by MALDI-TOFMS have focused on proteins and peptides, analysis of lipids has increased dramatically in recent years. This review gives an overview of the factors to consider when analyzing lipids directly from tissue and some recent examples of the use of MALDI-TOFMS for the direct profiling of lipids in tissue.

Original languageEnglish (US)
Pages (from-to)2822-2829
Number of pages8
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume877
Issue number26
DOIs
StatePublished - Sep 15 2009
Externally publishedYes

Keywords

  • Direct profiling
  • Lipids
  • MALDI
  • MS/MS
  • Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Cell Biology
  • Clinical Biochemistry

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