Direct observation of uterotonic drug use at public health facility-based deliveries in four districts in India

Cynthia K. Stanton, Nitya N. Deepak, Ashalata A. Mallapur, Geetanjali M. Katageri, Luke C Mullany, Alissa Koski, Ellie Mirzabagi

Research output: Contribution to journalArticle

Abstract

Objective To describe intrapartum uterotonic drug use and related behaviors in public health facility-based deliveries and to describe drug storage conditions in associated pharmacies. Methods A descriptive study was conducted between August and November 2011 to document practices related to uterotonic administration and storage based on direct observation of deliveries at public health facilities in four Indian districts (n = 97, n = 89, n = 91, and n = 89) with contrasting maternal health and socioeconomic indicators. Results Uterotonic drug use before and after delivery was common among the 366 study participants. Labor augmentation rates ranged from 53.5%-93.0% of deliveries across districts, with many receiving multiple uterotonics and administration via intramuscular injection or intravenous push. Uterotonic use following delivery ranged from 78.6%-99.1% across districts, with correct use of uterotonics for postpartum hemorrhage prevention varying from 6.0%-8.8% in Uttar Pradesh and 41.2%-76.4% in Karnataka. Active management of the third stage of labor following Indian guidelines was less than 10% in all districts. Storage of uterotonics at room temperature was common. Conclusion Given that labor augmentation is nearly routine and at odds with Indian guideline recommendations, rigorous research is needed to assess maternal and fetal outcomes of current versus guidelines-based practice. Active management of the third stage of labor as per Indian guidelines was minimal.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume127
Issue number1
DOIs
StatePublished - Oct 1 2014

Fingerprint

Public Facilities
Health Facilities
Third Labor Stage
India
Public Health
Observation
Guidelines
Drug Storage
Pharmaceutical Preparations
Postpartum Hemorrhage
Pharmacies
Intramuscular Injections
Practice Guidelines
Mothers
Temperature
Research

Keywords

  • Active management of the third stage of labor
  • Drug storage
  • India
  • Labor augmentation
  • Methylergometrine
  • Misoprostol
  • Oxytocin
  • Uterotonics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Direct observation of uterotonic drug use at public health facility-based deliveries in four districts in India. / Stanton, Cynthia K.; Deepak, Nitya N.; Mallapur, Ashalata A.; Katageri, Geetanjali M.; Mullany, Luke C; Koski, Alissa; Mirzabagi, Ellie.

In: International Journal of Gynecology and Obstetrics, Vol. 127, No. 1, 01.10.2014, p. 25-30.

Research output: Contribution to journalArticle

Stanton, Cynthia K. ; Deepak, Nitya N. ; Mallapur, Ashalata A. ; Katageri, Geetanjali M. ; Mullany, Luke C ; Koski, Alissa ; Mirzabagi, Ellie. / Direct observation of uterotonic drug use at public health facility-based deliveries in four districts in India. In: International Journal of Gynecology and Obstetrics. 2014 ; Vol. 127, No. 1. pp. 25-30.
@article{86dfcd400c4e4af8ac410a85519ff124,
title = "Direct observation of uterotonic drug use at public health facility-based deliveries in four districts in India",
abstract = "Objective To describe intrapartum uterotonic drug use and related behaviors in public health facility-based deliveries and to describe drug storage conditions in associated pharmacies. Methods A descriptive study was conducted between August and November 2011 to document practices related to uterotonic administration and storage based on direct observation of deliveries at public health facilities in four Indian districts (n = 97, n = 89, n = 91, and n = 89) with contrasting maternal health and socioeconomic indicators. Results Uterotonic drug use before and after delivery was common among the 366 study participants. Labor augmentation rates ranged from 53.5{\%}-93.0{\%} of deliveries across districts, with many receiving multiple uterotonics and administration via intramuscular injection or intravenous push. Uterotonic use following delivery ranged from 78.6{\%}-99.1{\%} across districts, with correct use of uterotonics for postpartum hemorrhage prevention varying from 6.0{\%}-8.8{\%} in Uttar Pradesh and 41.2{\%}-76.4{\%} in Karnataka. Active management of the third stage of labor following Indian guidelines was less than 10{\%} in all districts. Storage of uterotonics at room temperature was common. Conclusion Given that labor augmentation is nearly routine and at odds with Indian guideline recommendations, rigorous research is needed to assess maternal and fetal outcomes of current versus guidelines-based practice. Active management of the third stage of labor as per Indian guidelines was minimal.",
keywords = "Active management of the third stage of labor, Drug storage, India, Labor augmentation, Methylergometrine, Misoprostol, Oxytocin, Uterotonics",
author = "Stanton, {Cynthia K.} and Deepak, {Nitya N.} and Mallapur, {Ashalata A.} and Katageri, {Geetanjali M.} and Mullany, {Luke C} and Alissa Koski and Ellie Mirzabagi",
year = "2014",
month = "10",
day = "1",
doi = "10.1016/j.ijgo.2014.04.014",
language = "English (US)",
volume = "127",
pages = "25--30",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Direct observation of uterotonic drug use at public health facility-based deliveries in four districts in India

AU - Stanton, Cynthia K.

AU - Deepak, Nitya N.

AU - Mallapur, Ashalata A.

AU - Katageri, Geetanjali M.

AU - Mullany, Luke C

AU - Koski, Alissa

AU - Mirzabagi, Ellie

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective To describe intrapartum uterotonic drug use and related behaviors in public health facility-based deliveries and to describe drug storage conditions in associated pharmacies. Methods A descriptive study was conducted between August and November 2011 to document practices related to uterotonic administration and storage based on direct observation of deliveries at public health facilities in four Indian districts (n = 97, n = 89, n = 91, and n = 89) with contrasting maternal health and socioeconomic indicators. Results Uterotonic drug use before and after delivery was common among the 366 study participants. Labor augmentation rates ranged from 53.5%-93.0% of deliveries across districts, with many receiving multiple uterotonics and administration via intramuscular injection or intravenous push. Uterotonic use following delivery ranged from 78.6%-99.1% across districts, with correct use of uterotonics for postpartum hemorrhage prevention varying from 6.0%-8.8% in Uttar Pradesh and 41.2%-76.4% in Karnataka. Active management of the third stage of labor following Indian guidelines was less than 10% in all districts. Storage of uterotonics at room temperature was common. Conclusion Given that labor augmentation is nearly routine and at odds with Indian guideline recommendations, rigorous research is needed to assess maternal and fetal outcomes of current versus guidelines-based practice. Active management of the third stage of labor as per Indian guidelines was minimal.

AB - Objective To describe intrapartum uterotonic drug use and related behaviors in public health facility-based deliveries and to describe drug storage conditions in associated pharmacies. Methods A descriptive study was conducted between August and November 2011 to document practices related to uterotonic administration and storage based on direct observation of deliveries at public health facilities in four Indian districts (n = 97, n = 89, n = 91, and n = 89) with contrasting maternal health and socioeconomic indicators. Results Uterotonic drug use before and after delivery was common among the 366 study participants. Labor augmentation rates ranged from 53.5%-93.0% of deliveries across districts, with many receiving multiple uterotonics and administration via intramuscular injection or intravenous push. Uterotonic use following delivery ranged from 78.6%-99.1% across districts, with correct use of uterotonics for postpartum hemorrhage prevention varying from 6.0%-8.8% in Uttar Pradesh and 41.2%-76.4% in Karnataka. Active management of the third stage of labor following Indian guidelines was less than 10% in all districts. Storage of uterotonics at room temperature was common. Conclusion Given that labor augmentation is nearly routine and at odds with Indian guideline recommendations, rigorous research is needed to assess maternal and fetal outcomes of current versus guidelines-based practice. Active management of the third stage of labor as per Indian guidelines was minimal.

KW - Active management of the third stage of labor

KW - Drug storage

KW - India

KW - Labor augmentation

KW - Methylergometrine

KW - Misoprostol

KW - Oxytocin

KW - Uterotonics

UR - http://www.scopus.com/inward/record.url?scp=84908290559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908290559&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2014.04.014

DO - 10.1016/j.ijgo.2014.04.014

M3 - Article

C2 - 25026891

AN - SCOPUS:84908290559

VL - 127

SP - 25

EP - 30

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 1

ER -