Abstract
Induction of mammary carcinomas in rats by a single exposure to a carcinogen during sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a) anthracene, became activated by the same G → A transition, the type of mutation induced by N-nitroso-N-methylurea. These results are consistent with the notion that Ha-ras-1 oncogenes are directly activated by the carcinogen during initiation of neoplasia.
Original language | English (US) |
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Pages (from-to) | 382-385 |
Number of pages | 4 |
Journal | Nature |
Volume | 315 |
Issue number | 6018 |
DOIs | |
State | Published - Dec 1 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- General