Abstract
The cellular mechanism(s) responsible for tumor-associated bone resorption in multiple myeloma remain uncertain. Both in vivo and in vitro evidence is presented for the direct resorption of bone by mouse plasmacytomas. Morphological examination of autopsy specimens from tumorbearing mice revealed in vivo erosion of bony surfaces at sites of tumor cell-bone matrix apposition. No osteoclastic bone resorptive activity was evident. Using a 45Ca-labelled, devitalized bone explant assay system, mouse myeloma cells caused the release of isotope at levels from 200-300% above control values. Control cells such as normal spleen lymphocytes and liver cells did not resorb bone. Demonstration of the ability of myeloma cells to independently destroy bone is important to the understanding of the causes of and development of chemotherapeutic approaches to myelomatous bone resorption.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-124 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1983 |
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ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Direct bone resorbing activity of murine myeloma cells. / McDonald, Daniel F.; Schofield, Brian H.; Prezioso, Elena M.; Adams, Vicki L.; Frondoza, Carmelita A.; Trivedi, Sudhir M.; Craig, Caren; Humphrey, Richard L.
In: Cancer Letters, Vol. 19, No. 2, 1983, p. 119-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Direct bone resorbing activity of murine myeloma cells
AU - McDonald, Daniel F.
AU - Schofield, Brian H.
AU - Prezioso, Elena M.
AU - Adams, Vicki L.
AU - Frondoza, Carmelita A.
AU - Trivedi, Sudhir M.
AU - Craig, Caren
AU - Humphrey, Richard L
PY - 1983
Y1 - 1983
N2 - The cellular mechanism(s) responsible for tumor-associated bone resorption in multiple myeloma remain uncertain. Both in vivo and in vitro evidence is presented for the direct resorption of bone by mouse plasmacytomas. Morphological examination of autopsy specimens from tumorbearing mice revealed in vivo erosion of bony surfaces at sites of tumor cell-bone matrix apposition. No osteoclastic bone resorptive activity was evident. Using a 45Ca-labelled, devitalized bone explant assay system, mouse myeloma cells caused the release of isotope at levels from 200-300% above control values. Control cells such as normal spleen lymphocytes and liver cells did not resorb bone. Demonstration of the ability of myeloma cells to independently destroy bone is important to the understanding of the causes of and development of chemotherapeutic approaches to myelomatous bone resorption.
AB - The cellular mechanism(s) responsible for tumor-associated bone resorption in multiple myeloma remain uncertain. Both in vivo and in vitro evidence is presented for the direct resorption of bone by mouse plasmacytomas. Morphological examination of autopsy specimens from tumorbearing mice revealed in vivo erosion of bony surfaces at sites of tumor cell-bone matrix apposition. No osteoclastic bone resorptive activity was evident. Using a 45Ca-labelled, devitalized bone explant assay system, mouse myeloma cells caused the release of isotope at levels from 200-300% above control values. Control cells such as normal spleen lymphocytes and liver cells did not resorb bone. Demonstration of the ability of myeloma cells to independently destroy bone is important to the understanding of the causes of and development of chemotherapeutic approaches to myelomatous bone resorption.
UR - http://www.scopus.com/inward/record.url?scp=0020960066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020960066&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(83)90145-3
DO - 10.1016/0304-3835(83)90145-3
M3 - Article
C2 - 6883303
AN - SCOPUS:0020960066
VL - 19
SP - 119
EP - 124
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -