Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age

Francisco J. Garcia-Palmer, Jordi Pericas, Juan C. Matamala, Pere Puigserver, María L. Bonet, Andreu Palou, Magdalena Gianotti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present work is to investigate the effect of starvation on brown adipose tissue thermogenic activity with aging. Interscapular brown adipose tissue from female Wistar rats of different ages was used; half of them were fed and the other half were starved for 24 hours. Mitochondria were isolated and mitochondrial protein content, GDP-binding, Cytochrome-c Oxidase activity and uncoupling protein levels were measured. Results show a decrease of all studied parameters, indicating a diminished thermogenic activity with age. The response to starvation is almost the same in all the parameters studied: a general reduction with starvation and a progressive disappearance of this response to starvation with aging. On the whole, these results would indicate a deficient regulation of brown adipose tissue thermogenic activity in old animals, as it happens in other animal models with an alterated thermogenesis.

Original languageEnglish (US)
Pages (from-to)1151-1161
Number of pages11
JournalBiochemistry and Molecular Biology International
Volume42
Issue number6
StatePublished - Sep 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

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