Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam

Robert M. Nalbandian, Raymond L. Henry, C. Lynne Burek, Clement A. Diglio, Arnold I. Goldman, Gregory W. Taylor, William H. Hoffman

Research output: Contribution to journalArticle

Abstract

Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalAmerican journal of hematology
Volume15
Issue number2
DOIs
StatePublished - Sep 1983

Keywords

  • cell adherence
  • endothelial cell culture
  • erythrocytes
  • piracetam
  • sickle cell disease

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Nalbandian, R. M., Henry, R. L., Burek, C. L., Diglio, C. A., Goldman, A. I., Taylor, G. W., & Hoffman, W. H. (1983). Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam. American journal of hematology, 15(2), 147-151. https://doi.org/10.1002/ajh.2830150206