Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis

Mari A. Kondo, Daisuke Fukudome, Dani R. Smith, Michela Gallagher, Atsushi Kamiya, Akira Sawa

Research output: Contribution to journalArticlepeer-review

Abstract

Recent clinical studies have suggested a role for immune/inflammatory responses in the pathophysiology of psychosis. However, a mechanistic understanding of this process and its application for drug discovery is underdeveloped. Here we assessed our recently developed cuprizone short-term exposure (CSE) mouse model across behavioral domains targeting neurocognitive and neuroaffective systems. We propose that the CSE model may be useful for understanding the mechanism associating inflammation and psychosis, with applications for drug discovery in that context.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalNeuroscience Research
Volume107
DOIs
StatePublished - Jun 1 2016

Keywords

  • Behavior
  • Cuprizone
  • Cuprizone short-term exposure (CSE)
  • Dimensional approach
  • Hippocampus
  • Inflammation
  • Psychosis
  • Research Domain Criteria (RDoC)

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis'. Together they form a unique fingerprint.

Cite this