Abstract
Recent clinical studies have suggested a role for immune/inflammatory responses in the pathophysiology of psychosis. However, a mechanistic understanding of this process and its application for drug discovery is underdeveloped. Here we assessed our recently developed cuprizone short-term exposure (CSE) mouse model across behavioral domains targeting neurocognitive and neuroaffective systems. We propose that the CSE model may be useful for understanding the mechanism associating inflammation and psychosis, with applications for drug discovery in that context.
Original language | English (US) |
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Pages (from-to) | 70-74 |
Number of pages | 5 |
Journal | Neuroscience Research |
Volume | 107 |
DOIs | |
State | Published - Jun 1 2016 |
Keywords
- Behavior
- Cuprizone
- Cuprizone short-term exposure (CSE)
- Dimensional approach
- Hippocampus
- Inflammation
- Psychosis
- Research Domain Criteria (RDoC)
ASJC Scopus subject areas
- General Neuroscience